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在资源有限的环境中推进小儿生殖器重建:一名年轻女孩的皮下阴蒂缩小成形术病例。

Advancing pediatric genital reconstruction in a resource-limited setting: A case of subtunical reduction clitoroplasty in a young girl.

作者信息

Shadrack Mathayo, Salim Mohammed Sultan, Ngiloi Petronilla, Bokhary Zaituni, Ngotta Victor, Alshafei Abdulrahman

机构信息

Muhimbili University of Health and Allied Science (MUHAS), P.O. box 65001, Dar es salaam, Tanzania; Department of pediatric Surgery, Muhimbili National Hospital (MNH), P.O. Box 65000, Dar es salaam, Tanzania; Department of Pediatric Surgery, Kilimanjaro Christian Medical Center, P.O. Box 3010, Moshi, Kilimanjaro, Tanzania; Kilimanjaro Christian Medical University, P.O. Box 2240, Moshi, Kilimanjaro, Tanzania.

Muhimbili University of Health and Allied Science (MUHAS), P.O. box 65001, Dar es salaam, Tanzania; Department of pediatric Surgery, Muhimbili National Hospital (MNH), P.O. Box 65000, Dar es salaam, Tanzania.

出版信息

Int J Surg Case Rep. 2025 Jun;131:111415. doi: 10.1016/j.ijscr.2025.111415. Epub 2025 May 8.

Abstract

BACKGROUND

Congenital anomalies, including clitoromegaly, are significant challenges, particularly in resource-limited settings where access to specialized care may be lacking. Clitoral enlargement is often associated with disorders of sexual differentiation, such as congenital adrenal hyperplasia. Managing such conditions in under-resourced environments requires specialized surgical expertise and collaborative approach.

CASE PRESENTATION

A 3-year-old girl from a resource-limited community was referred for management of clitoromegaly diagnosed since birth. Hormonal assays showed slightly elevated 17-hydroxyprogesterone, suggesting congenital adrenal hyperplasia with a 46XX karyotype. A diagnostic laparoscopy was performed, confirming normal female internal structures. Her parents were concerned about psychological implications. Subtunical clitoroplasty, an advanced reconstructive procedure preserving neurovascular function with labial reconstruction and vaginoplasty were recommended by visiting pediatric surgeons to restore a more typical anatomical appearance.

DISCUSSION

The subtunical clitoroplasty was successfully performed, achieving favorable aesthetic and functional outcomes. The involvement of global health surgeons from a developed country facilitated the application of advanced techniques despite local resource constraints. This case emphasizes the value of global health collaborations in providing high-quality care in resource-limited settings. Ethical considerations, including the child's future autonomy and the psychological impact of surgery, were carefully addressed with the family.

CONCLUSION

This case highlights the successful surgical management of clitoromegaly in a child from a resource-limited setting through subtunical clitoroplasty. It underscores the importance of international collaboration in advancing pediatric genital reconstruction and the need for ongoing support for both medical and psychosocial outcomes in such cases. Further research is needed to evaluate long-term outcomes in similar settings.

摘要

背景

先天性异常,包括阴蒂肥大,是重大挑战,尤其是在缺乏获得专科护理途径的资源有限地区。阴蒂增大通常与性分化障碍有关,如先天性肾上腺皮质增生症。在资源匮乏的环境中处理此类病症需要专业的外科手术专业知识和协作方法。

病例介绍

一名来自资源有限社区的3岁女孩因出生后被诊断为阴蒂肥大而前来就诊。激素检测显示17-羟孕酮略有升高,提示46XX核型的先天性肾上腺皮质增生症。进行了诊断性腹腔镜检查,证实女性内部结构正常。她的父母担心心理影响。来访的儿科外科医生建议进行保留神经血管功能的先进重建手术——阴蒂皮下成形术,并进行阴唇重建和阴道成形术,以恢复更典型的解剖外观。

讨论

阴蒂皮下成形术成功实施,取得了良好的美学和功能效果。尽管当地资源有限,但来自发达国家的全球健康外科医生的参与促进了先进技术的应用。该病例强调了全球健康合作在资源有限地区提供高质量护理方面的价值。与患儿家庭仔细讨论了包括儿童未来自主权和手术心理影响在内的伦理考量。

结论

本病例突出了通过阴蒂皮下成形术成功对一名来自资源有限地区儿童的阴蒂肥大进行手术治疗。它强调了国际合作在推进小儿生殖器重建方面的重要性,以及在此类病例中对医疗和心理社会结果持续提供支持的必要性。需要进一步研究以评估类似环境中的长期结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1145/12139512/98488afa7c31/gr1.jpg

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