尼日利亚北部脊髓损伤患者中上肢有氧运动加全身运动与单纯全身运动的效果比较：一项随机对照试验方案

Effects of upper-limb aerobic exercise plus general exercise versus general exercise alone among patients with spinal cord injury in northern Nigeria: A protocol for a randomized controlled trial.

作者信息

Gujba Fatima Kachalla, Maharaj Sonill Sooknunan, Ibrahim Aminu Alhassan

机构信息

Department of Physiotherapy, School of Health Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.

Department of Medical Rehabilitation, College of Medical Sciences, University of Maiduguri, Maiduguri, Borno State, Nigeria.

出版信息

PLoS One. 2025 May 12;20(5):e0321932. doi: 10.1371/journal.pone.0321932. eCollection 2025.

DOI:10.1371/journal.pone.0321932

PMID:40354458

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12068697/

Abstract

INTRODUCTION

Spinal cord injury (SCI) is a devastating injury often associated with immobility, leading to numerous complications, with cardiovascular disorders being among the major causes of mortality. Upper-limb aerobic exercise (ULAE) may help to retrain and regain some of the abilities lost through SCI and minimize secondary complications. The purpose of this study is to determine the effects of ULAE plus general exercise compared to the same general exercise on cardiovascular parameters, functional independence, and quality of life among patients with SCI in northern Nigeria.

METHOD

This is a multicenter, assessor-blind, parallel group, randomized controlled superiority trial to be conducted among SCI patients attending three tertiary hospitals in Kano State, northern Nigeria. Participants fulfilling the study criteria will be randomized into either ULAE (arm ergometer and overhead pulley exercises) plus general exercise group or general exercise only group. Both groups will receive their respective interventions three times per week for 8 weeks. The primary outcomes will be rate pressure product (calculated as systolic blood pressure x heart rate) and functional independence. The secondary outcomes will be blood pressure and quality of life. All outcomes will be assessed at baseline, 8 weeks post-intervention, and at 14weeks follow-up.

DISCUSSION

This study will be the first to determine the effects of ULAE plus general exercise versus general exercise alone among patients with SCI in northern Nigeria. The outcome of this study could provide valuable guidance for rehabilitation professionals in selecting a low-cost and effective intervention for patients with SCI, particularly in resource-constrained settings.

TRIAL REGISTRATION

Pan African Clinical Registry (PACTR202306580460880). Registered on June 12, 2023.

摘要

引言

脊髓损伤（SCI）是一种严重的损伤，常与行动不便相关，会导致多种并发症，心血管疾病是主要的死亡原因之一。上肢有氧运动（ULAE）可能有助于重新训练并恢复因脊髓损伤而丧失的部分能力，并将继发性并发症降至最低。本研究的目的是确定与单纯进行一般运动相比，上肢有氧运动加一般运动对尼日利亚北部脊髓损伤患者心血管参数、功能独立性和生活质量的影响。

方法

这是一项多中心、评估者盲法、平行组、随机对照优势试验，将在尼日利亚北部卡诺州的三家三级医院的脊髓损伤患者中进行。符合研究标准的参与者将被随机分为上肢有氧运动（臂力计和头顶滑轮运动）加一般运动组或仅进行一般运动组。两组将每周接受各自的干预三次，持续8周。主要结局指标将是心率血压乘积（计算为收缩压×心率）和功能独立性。次要结局指标将是血压和生活质量。所有结局指标将在基线、干预后8周和随访14周时进行评估。