Chen Buxin, Zhang Zheng, Xia Dan, Sidky Emil Y, Pan Xiaochuan
Department of Radiology, The University of Chicago, Chicago, IL 60637, United States of America.
Department of Radiation and Cellular Oncology, The University of Chicago, Chicago, IL 60637, United States of America.
Phys Med Biol. 2025 May 22;70(11):115005. doi: 10.1088/1361-6560/add789.
We investigate and develop an algorithm to invert the well-established non-linear data model in standard computed tomography (CT) for numerically accurate and stable reconstruction of multi (⩾2)-basis images directly from a set of conventional data collected with a single spectrum in standard CT.Using the basis-region technique to reduce the number of voxel values, i.e. unknowns, in the basis images to be reconstructed and the volume-conservation constraint to augment conventional data, we formulate the reconstruction problem (i.e. the inverse problem) as a non-convex optimization program and develop the dynamic non-convex primal-dual (dNCPD) algorithm to empirically solve the optimization program for numerically accurate and stable reconstruction of multi-basis images from conventional data.We conduct studies to verify numerically the reconstruction accuracy of the dNCPD algorithm with simulated conventional data and also studies to evaluate the stability of the dNCPD algorithm with real conventional data that contain noise and other physical factors. The study results reveal that the dNCPD algorithm can numerically accurately and stably yield multi-basis images and virtual monochromatic images from conventional data.The work can be of theoretic interest and practical implication as it reveals the possibility of yielding multi-basis images from conventional data in standard CT, instead of data collected in dual-energy, multi-spectra, or photon-counting CT.
我们研究并开发了一种算法,用于对标准计算机断层扫描(CT)中成熟的非线性数据模型进行反演,以便直接从标准CT中用单光谱采集的一组传统数据精确且稳定地数值重建多(⩾2)基图像。利用基区域技术减少待重建基图像中的体素值数量,即未知数数量,并利用体积守恒约束增强传统数据,我们将重建问题(即反问题)表述为一个非凸优化程序,并开发了动态非凸原始对偶(dNCPD)算法,以通过经验求解该优化程序,从而从传统数据中精确且稳定地数值重建多基图像。我们进行研究以用模拟传统数据数值验证dNCPD算法的重建精度,还进行研究以用包含噪声和其他物理因素的真实传统数据评估dNCPD算法的稳定性。研究结果表明,dNCPD算法能够从传统数据中精确且稳定地生成多基图像和虚拟单色图像。这项工作具有理论意义和实际意义,因为它揭示了在标准CT中从传统数据而非双能、多光谱或光子计数CT采集的数据中生成多基图像的可能性。