Ying Xihong, Zhao Qiuyan, Wu Yi, Deng Shasha, Ma Qing, Fang Ronghua
General Practice Ward/International Medical Center Ward, General Practice Medical Center, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, China.
General Practice Ward/International Medical Center Ward, General Practice Medical Center, West China Hospital, Sichuan University, Chengdu, China.
PLoS One. 2025 May 13;20(5):e0323324. doi: 10.1371/journal.pone.0323324. eCollection 2025.
Sleep disorders are a common symptom in Ankylosing Spondylitis (AS) patients. In this cross-sectional study, we aimed to understand the current status of sleep disorders in AS patients and to analyze potential factors influencing sleep disorders.
A total of 205 AS patients were recruited in the survey. The content included the self-designed demographic data questionnaire, The MOS 36-Item Short Form Health Survey (SF-36), Visual Analogue Scale (VAS), Multidimensional Fatigue Inventory (MF-20), Self-Rating Anxiety and Depression Scale, Pittsburgh Sleep Quality Index questionnaire (PSQI), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI) and Bath Ankylosing Spondylitis Metrology Index (BASMI). These data were analyzed using chi-square test, independent sample t-test, Mann-Whitney U test, Pearson correlation analysis, single-factor linear regression analysis, and multiple linear stepwise regression analysis.
The results showed that the average sleep total score was 8.82 ± 4.146, and the prevalence of sleep disorders was approximately 66.8% in AS patients. Age (F = 29.710, P < 0.001), disease duration (F = 13.025, P < 0.001), anxiety (F = 36.060, P < 0.001), depression (F = 11.808, P < 0.001), and quality of life (t = 6.665, P < 0.001) significantly impacted the sleep total score. Pearson correlation analysis revealed a significant negative correlation between SF-36 total score and sleep total score (r = ‒0.449, P < 0.01), while positive correlations were observed for VAS score, fatigue, anxiety, depression, BASDAI, BASFI, BASMI, age, and disease duration (all P < 0.01). Multivariate analysis showed that age, disease duration, nocturnal pain VAS score, total back pain VAS score, peripheral joint pain VAS score, total fatigue score, total anxiety score, and BASMI total score significantly predicted sleep total score (R² = 0.755, F = 45.334, P < 0.001).
These findings suggest that medical professionals should pay increased attention to the observed associations between sleep disorders and clinical factors in AS patients, and consider implementing targeted interventions to address sleep-related issues.
睡眠障碍是强直性脊柱炎（AS）患者的常见症状。在这项横断面研究中，我们旨在了解AS患者睡眠障碍的现状，并分析影响睡眠障碍的潜在因素。
共招募了205例AS患者进行调查。调查内容包括自行设计的人口统计学数据问卷、医学结局研究简明健康调查（SF-36）、视觉模拟评分法（VAS）、多维疲劳量表（MF-20）、自评焦虑与抑郁量表、匹兹堡睡眠质量指数问卷（PSQI）、巴斯强直性脊柱炎疾病活动指数（BASDAI）、巴斯强直性脊柱炎功能指数（BASFI）和巴斯强直性脊柱炎测量指数（BASMI）。采用卡方检验、独立样本t检验、曼-惠特尼U检验、Pearson相关分析、单因素线性回归分析和多元线性逐步回归分析这些数据。
结果显示，AS患者的平均睡眠总分是8.82±4.146，睡眠障碍的患病率约为66.8%。年龄（F = 29.710，P < 0.001）、病程（F = 13.025，P < 0.001）、焦虑（F = 36.060，P < 0.001）、抑郁（F = 11.808，P < 0.001）和生活质量（t = 6.665，P < 0.001）对睡眠总分有显著影响。Pearson相关分析显示，SF-36总分与睡眠总分呈显著负相关（r = -0.449，P < 0.01），而VAS评分、疲劳、焦虑、抑郁、BASDAI、BASFI、BASMI、年龄和病程呈正相关（均P < 0.01）。多因素分析显示，年龄、病程、夜间疼痛VAS评分、背部总疼痛VAS评分、外周关节疼痛VAS评分、总疲劳评分、总焦虑评分和BASMI总分显著预测睡眠总分（R² = 0.755，F = 45.334，P < 0.001）。
这些研究结果表明，医学专业人员应更加关注AS患者睡眠障碍与临床因素之间的关联，并考虑实施针对性干预措施来解决与睡眠相关的问题。
