颤藻科中的抗白血病活性：从鞘丝藻属中分离出脱溴海兔毒素。
Antileukemia activity in the Osillatoriaceae: isolation of Debromoaplysiatoxin from Lyngbya.
作者信息
Mynderse J S, Moore R E, Kashiwagi M, Norton T R
出版信息
Science. 1977 Apr 29;196(4289):538-40. doi: 10.1126/science.403608.
PMID:403608
Abstract
Chloroform extracts of several seaweeds, of the family Oscillatoriaceae, from Enewetak Atoll, Marshall Islands, display activity against P-388 lymphocytic mouse leukemia. A P-388 active compound, debromoaplysiatoxin, has been isolated from Lyngbya gracilis and characterized. This compound also has dermonecrotic activity and may be the dermatitis-producing substance in L. majuscula, the causative agent of "swimmers' itch" outbreaks in Hawaiian waters.
摘要
从马绍尔群岛埃尼威托克环礁采集的几种颤藻科海藻的氯仿提取物，对P - 388淋巴细胞性小鼠白血病显示出活性。一种具有P - 388活性的化合物——脱溴海兔毒素，已从纤细席藻中分离出来并进行了表征。这种化合物也具有皮肤坏死活性，可能是大团扇藻中产生皮炎的物质，大团扇藻是夏威夷海域“游泳者瘙痒”疫情的病原体。
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