Tsvetkova T, Konstantinova V, Riakhovska S
Vutr Boles. 1985;24(2):82-8.
The purpose of the study is to investigate and juxtapose the cytochemical characteristics of ribonucleoproteins (RNP) and deoxyribonucleoproteins (DNP) in the lymphocytes of patients with rheumatoid arthritis (RA), of healthy lymphocytes and lymphocytes blast-transformed by phytohemagglutinins. Significant differences in the staining of lymphocytes for nucleoproteins were established in all 54 patients with RA studied. The unidirectional changes in the morphological form of the staining for RNP and DNP in blast-transformed lymphocytes and lymphocytes in RA is, most likely, in connection with the transition of the latter into active functional state and their participation in the forming of the immune inflammation. No significant difference was established in the dependence on the RA form--sero-positive or sero-negative. Regardless of the negative serological samples in the second form, there were some changes in the lymphocytes--carriers of immune reactions in organism.
本研究的目的是调查并比较类风湿性关节炎（RA）患者淋巴细胞、健康淋巴细胞以及经植物血凝素刺激发生胚细胞转化的淋巴细胞中核糖核蛋白（RNP）和脱氧核糖核蛋白（DNP）的细胞化学特征。在所研究的全部54例RA患者中，均确定了淋巴细胞中核蛋白染色的显著差异。胚细胞转化淋巴细胞和RA患者淋巴细胞中RNP和DNP染色形态的单向变化，很可能与后者转变为活跃功能状态及其参与免疫炎症形成有关。未发现其与RA类型（血清阳性或血清阴性）存在显著差异。尽管第二种类型血清学样本呈阴性，但机体免疫反应载体淋巴细胞仍有一些变化。
