Li Kelei, Li Junwei, Wang Tiebao, Wang Xin, Qi Yumin, Zhao Lichen, Cui Chunxiang
Hebei Key Laboratory of New Functional Materials, School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300400, China.
Materials (Basel). 2025 Apr 30;18(9):2057. doi: 10.3390/ma18092057.
In the field of degradable metals, Zn-based implants have gradually gained more attention. However, the relatively slow degradation rate compared with the healing rate of the damaged bone tissue, along with the excessive Zn release during the degradation process, limit the application of Zn-based implants. The use of intermetallic compounds with more negative electrode potentials as sacrificial anodes of Zn-based implants is likely to be a feasible approach to resolve this contradiction. In this work, three intermetallic compounds, MgZn, CaZn, and CaMgZn, were prepared. The phase structures, microstructures, and relevant properties, such as thermal stability, in vitro degradation properties, and cytotoxicity of the compounds, were investigated. The XRD patterns indicate that the MgZn and CaZn specimens contain single-phase MgZn and CaZn, respectively, while the CaMgZn specimen contains MgCa and CaMgZn phases. After purifying treatment in 0.9% NaCl solution, high purity CaMgZn phase was obtained. Thermal stability tests suggest that the MgZn and CaZn specimens possess good thermal stability below 773 K. However, the CaMgZn specimen melted at around 739.1 K. Polarization curve tests show that the corrosion potentials of MgZn, CaZn, and CaMgZn in simulated body fluid (SBF) were -1.063 V, -1.289 V, and -1.432 V, which were all more negative than that of the pure Zn specimen (-1.003 V). Clearly, these compounds can act as sacrificial anodes in Zn-based implants. The immersion tests indicate that these compounds were degraded according to the atomic ratio of the elements in each compound. Besides that, the compounds can efficiently induce Ca-P deposition in SBF. Cytotoxicity tests demonstrate that the 10% extracts prepared from these compounds exhibit good cell activity on MC3T3-E1 cells.
在可降解金属领域，锌基植入物逐渐受到更多关注。然而，与受损骨组织的愈合速度相比，其降解速度相对较慢，且在降解过程中锌释放过多，限制了锌基植入物的应用。使用电极电位更负的金属间化合物作为锌基植入物的牺牲阳极可能是解决这一矛盾的可行方法。在这项工作中，制备了三种金属间化合物MgZn、CaZn和CaMgZn。研究了这些化合物的相结构、微观结构以及相关性能，如热稳定性、体外降解性能和细胞毒性。XRD图谱表明，MgZn和CaZn试样分别包含单相MgZn和CaZn，而CaMgZn试样包含MgCa和CaMgZn相。在0.9% NaCl溶液中进行纯化处理后，获得了高纯度的CaMgZn相。热稳定性测试表明，MgZn和CaZn试样在773 K以下具有良好的热稳定性。然而，CaMgZn试样在约739.1 K时熔化。极化曲线测试表明，MgZn、CaZn和CaMgZn在模拟体液（SBF）中的腐蚀电位分别为-1.063 V、-1.289 V和-1.432 V，均比纯锌试样（-1.003 V）更负。显然，这些化合物可以作为锌基植入物中的牺牲阳极。浸泡试验表明，这些化合物按照每种化合物中元素的原子比进行降解。除此之外，这些化合物能够在SBF中有效诱导Ca-P沉积。细胞毒性测试表明，由这些化合物制备的10%提取物对MC3T3-E1细胞表现出良好的细胞活性。
