Xia Dandan, Qin Yu, Guo Hui, Wen Peng, Lin Hong, Voshage Maximilian, Schleifenbaum Johannes Henrich, Cheng Yan, Zheng Yufeng
Department of Dental Materials, Peking University School and Hospital of Stomatology, Beijing, 100081, China.
National Center of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing Key Laboratory of Digital Stomatology, Research Center of Engineering and Technology for Digital Dentistry Ministry of Health, NMPA Key Laboratory for Dental Materials, Beijing, 100081, China.
Bioact Mater. 2022 Apr 1;19:12-23. doi: 10.1016/j.bioactmat.2022.03.010. eCollection 2023 Jan.
Additive manufacturing has received attention for the fabrication of medical implants that have customized and complicated structures. Biodegradable Zn metals are revolutionary materials for orthopedic implants. In this study, pure Zn porous scaffolds with diamond structures were fabricated using customized laser powder bed fusion (L-PBF) technology. First, the mechanical properties, corrosion behavior, and biocompatibility of the pure Zn porous scaffolds were characterized . The scaffolds were then implanted into the rabbit femur critical-size bone defect model for 24 weeks. The results showed that the pure Zn porous scaffolds had compressive strength and rigidity comparable to those of cancellous bone, as well as relatively suitable degradation rates for bone regeneration. A benign host response was observed using hematoxylin and eosin (HE) staining of the heart, liver, spleen, lungs, and kidneys. Moreover, the pure Zn porous scaffold showed good biocompatibility and osteogenic promotion ability . This study showed that pure Zn porous scaffolds with customized structures fabricated using L-PBF represent a promising biodegradable solution for treating large bone defects.
增材制造因可制造具有定制化和复杂结构的医用植入物而受到关注。可生物降解的锌金属是用于骨科植入物的革命性材料。在本研究中，采用定制的激光粉末床熔融（L-PBF）技术制造了具有菱形结构的纯锌多孔支架。首先，对纯锌多孔支架的力学性能、腐蚀行为和生物相容性进行了表征。然后将支架植入兔股骨临界尺寸骨缺损模型中24周。结果表明，纯锌多孔支架的抗压强度和刚度与松质骨相当，并且具有相对适合骨再生的降解速率。通过对心脏、肝脏、脾脏、肺和肾脏进行苏木精-伊红（HE）染色观察到良性宿主反应。此外，纯锌多孔支架表现出良好的生物相容性和成骨促进能力。本研究表明，采用L-PBF制造的具有定制结构的纯锌多孔支架是治疗大骨缺损的一种有前景的可生物降解解决方案。
