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一种基于深度卷积神经网络的利用MRI图像早期检测阿尔茨海默病的有效方法。

An efficient method for early Alzheimer's disease detection based on MRI images using deep convolutional neural networks.

作者信息

Dardouri Samia

机构信息

Department of Computer Science, College of Computing and Information Technology, Shaqra University, Shaqraa, Saudi Arabia.

出版信息

Front Artif Intell. 2025 Apr 29;8:1563016. doi: 10.3389/frai.2025.1563016. eCollection 2025.

DOI:10.3389/frai.2025.1563016
PMID:40365577
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12069281/
Abstract

Alzheimer's disease (AD) is a progressive, incurable neurological disorder that leads to a gradual decline in cognitive abilities. Early detection is vital for alleviating symptoms and improving patient quality of life. With a shortage of medical experts, automated diagnostic systems are increasingly crucial in healthcare, reducing the burden on providers and enhancing diagnostic accuracy. AD remains a global health challenge, requiring effective early detection strategies to prevent its progression and facilitate timely intervention. In this study, a deep convolutional neural network (CNN) architecture is proposed for AD classification. The model, consisting of 6,026,324 parameters, uses three distinct convolutional branches with varying lengths and kernel sizes to improve feature extraction. The OASIS dataset used includes 80,000 MRI images sourced from Kaggle, categorized into four classes: non-demented (67,200 images), very mild demented (13,700 images), mild demented (5,200 images), and moderate demented (488 images). To address the dataset imbalance, a data augmentation technique was applied. The proposed model achieved a remarkable 99.68% accuracy in distinguishing between the four stages of Alzheimer's: Non-Dementia, Very Mild Dementia, Mild Dementia, and Moderate Dementia. This high accuracy highlights the model's potential for real-time analysis and early diagnosis of AD, offering a promising tool for healthcare professionals.

摘要

阿尔茨海默病(AD)是一种进行性、无法治愈的神经疾病,会导致认知能力逐渐下降。早期检测对于缓解症状和提高患者生活质量至关重要。由于医学专家短缺,自动化诊断系统在医疗保健中变得越来越关键,可减轻医疗人员的负担并提高诊断准确性。AD仍然是一项全球性的健康挑战,需要有效的早期检测策略来防止其进展并促进及时干预。在本研究中,提出了一种用于AD分类的深度卷积神经网络(CNN)架构。该模型由6,026,324个参数组成,使用三个不同长度和内核大小的卷积分支来改进特征提取。所使用的OASIS数据集包括从Kaggle获取的80,000张MRI图像,分为四类:非痴呆(67,200张图像)、极轻度痴呆(13,700张图像)、轻度痴呆(5,200张图像)和中度痴呆(488张图像)。为了解决数据集不平衡问题,应用了数据增强技术。所提出的模型在区分阿尔茨海默病的四个阶段:非痴呆、极轻度痴呆、轻度痴呆和中度痴呆方面取得了99.68%的显著准确率。这种高准确率凸显了该模型在AD实时分析和早期诊断方面的潜力,为医疗保健专业人员提供了一个有前景的工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b39/12069281/d6539236dc94/frai-08-1563016-g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b39/12069281/d6539236dc94/frai-08-1563016-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b39/12069281/725eb5fd2006/frai-08-1563016-g001.jpg
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本文引用的文献

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Early Alzheimer's Disease Detection: A Review of Machine Learning Techniques for Forecasting Transition from Mild Cognitive Impairment.早期阿尔茨海默病检测:用于预测从轻度认知障碍转变的机器学习技术综述
Diagnostics (Basel). 2024 Aug 13;14(16):1759. doi: 10.3390/diagnostics14161759.
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Deep Learning for Alzheimer's Disease Prediction: A Comprehensive Review.用于阿尔茨海默病预测的深度学习:全面综述
Diagnostics (Basel). 2024 Jun 17;14(12):1281. doi: 10.3390/diagnostics14121281.
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Categorization of Alzheimer's disease stages using deep learning approaches with McNemar's test.
使用深度学习方法和麦克尼马尔检验对阿尔茨海默病阶段进行分类。
PeerJ Comput Sci. 2024 Feb 21;10:e1877. doi: 10.7717/peerj-cs.1877. eCollection 2024.
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A novel CNN architecture for accurate early detection and classification of Alzheimer's disease using MRI data.一种使用 MRI 数据进行阿尔茨海默病早期准确检测和分类的新型卷积神经网络架构。
Sci Rep. 2024 Feb 12;14(1):3463. doi: 10.1038/s41598-024-53733-6.
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Deep Learning-Based Ensembling Technique to Classify Alzheimer's Disease Stages Using Functional MRI.基于深度学习的集成技术,利用功能磁共振成像对阿尔茨海默病进行分期分类。
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Classification of Alzheimer's disease stages from magnetic resonance images using deep learning.利用深度学习从磁共振图像对阿尔茨海默病阶段进行分类。
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An Efficient Ensemble Approach for Alzheimer's Disease Detection Using an Adaptive Synthetic Technique and Deep Learning.一种使用自适应合成技术和深度学习的阿尔茨海默病检测高效集成方法。
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Alzheimer's disease diagnosis and classification using deep learning techniques.使用深度学习技术进行阿尔茨海默病的诊断与分类。
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Revolutionizing the Early Detection of Alzheimer's Disease through Non-Invasive Biomarkers: The Role of Artificial Intelligence and Deep Learning.通过非侵入性生物标志物实现阿尔茨海默病的早期检测的革命:人工智能和深度学习的作用。
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