Department of Computer Science, University of Texas, Austin, TX 78712, USA.
Department of Electrical and Computer Engineering, California State University, Fullerton, CA 92831, USA.
Sensors (Basel). 2023 Sep 30;23(19):8192. doi: 10.3390/s23198192.
Alzheimer's disease (AD) is a neurodegenerative disease that can cause dementia and result in a severe reduction in brain function, inhibiting simple tasks, especially if no preventative care is taken. Over 1 in 9 Americans suffer from AD-induced dementia, and unpaid care for people with AD-related dementia is valued at USD 271.6 billion. Hence, various approaches have been developed for early AD diagnosis to prevent its further progression. In this paper, we first review other approaches that could be used for the early detection of AD. We then give an overview of our dataset and propose a deep convolutional neural network (CNN) architecture consisting of 7,866,819 parameters. This model comprises three different convolutional branches, each having a different length. Each branch is comprised of different kernel sizes. This model can predict whether a patient is non-demented, mild-demented, or moderately demented with a 99.05% three-class accuracy. In summary, the deep CNN model demonstrated exceptional accuracy in the early diagnosis of AD, offering a significant advancement in the field and the potential to improve patient care.
阿尔茨海默病(AD)是一种神经退行性疾病,可导致痴呆,并导致大脑功能严重下降,抑制简单的任务,特别是如果没有采取预防措施的话。超过 1/9 的美国人患有 AD 引起的痴呆症,与 AD 相关的痴呆症患者的无薪护理价值 2716 亿美元。因此,已经开发了各种方法来进行早期 AD 诊断,以防止其进一步发展。在本文中,我们首先回顾了其他可用于早期检测 AD 的方法。然后,我们概述了我们的数据集,并提出了一个由 7866819 个参数组成的深度卷积神经网络(CNN)架构。该模型由三个不同的卷积分支组成,每个分支的长度都不同。每个分支都包含不同的核大小。该模型可以预测患者是非痴呆、轻度痴呆还是中度痴呆,准确率为 99.05%。总的来说,深度 CNN 模型在 AD 的早期诊断中表现出了出色的准确性,在该领域取得了重大进展,并有可能改善患者的护理。