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大鼠条件性抑制的消退、恢复及自发恢复与条件性抑制效能的稳定性

Extinction, reinstatement and spontaneous recovery of conditioned suppression in rats and the stability of conditioned inhibitor performance.

作者信息

Wesierska M, Zieliński K

出版信息

Acta Neurobiol Exp (Wars). 1985;45(1-2):1-24.

PMID:4036671
Abstract

Acquisition of the suppressive properties of a conditioned stimulus (CS), terminating with shock, and of the attenuating properties of the conditioned inhibitor (CI), signaling that shock will not be given at the end of the CS, proceed at similar rates. The attenuation of suppression exerted by the CI and the decrement of the suppression due to extinction differed in both the time course and the distribution of barpresses within the CS duration. After extinction the CS still retained some suppressing properties, which were limited to the last 20-30 s, whereas the CI attenuated the suppression throughout the duration of the CS. Extinction of the suppressive properties of the CS did not change the attenuating properties of the CI. The recovery of the suppressive properties of the CS after presentations of unsignaled reinstating shocks or after a long pause in experimental sessions was incomplete and shortlasting. Both procedures did not change the properties of the CS presented in compound with the CI.

摘要

获得以电击终止的条件刺激(CS)的抑制特性,以及条件性抑制物(CI)的衰减特性(即表明在CS结束时不会给予电击),其进展速度相似。CI所施加的抑制衰减和消退导致的抑制减少在时间进程以及CS持续时间内的压杆分布上均有所不同。消退后,CS仍保留一些抑制特性,这些特性仅限于最后20 - 30秒,而CI在CS的整个持续时间内都会减弱抑制。CS抑制特性的消退并未改变CI的衰减特性。在呈现无信号的恢复电击后或在实验过程中长时间暂停后,CS抑制特性的恢复是不完全且短暂的。这两种程序都没有改变与CI复合呈现的CS的特性。

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