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蚊子的性别决定：最新进展与应用

Mosquito sex determination: recent advances and applications.

作者信息

Hempel Melanie, Warren Joseph D, Liang Jiangtao, Hughes Christen, Tu Zhijian

机构信息

Department of Biochemistry and the Fralin Life Sciences Institute Virginia Tech, Blacksburg, VA 24061, USA.

Department of Biochemistry and the Fralin Life Sciences Institute Virginia Tech, Blacksburg, VA 24061, USA.

出版信息

Curr Opin Insect Sci. 2025 Oct;71:101385. doi: 10.1016/j.cois.2025.101385. Epub 2025 May 13.

DOI:10.1016/j.cois.2025.101385
PMID:40368280
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12331425/
Abstract

Mosquitoes have evolved divergent sex-determining chromosomes, and they employ diverse primary signals for sex determination. As only females feed on vertebrate blood, manipulating genes involved in sex determination can facilitate genetic control measures for mosquito-borne infectious diseases, such as dengue and malaria. We highlight new advances in mosquito sex determination, describe innovative applications, and discuss relevant evolutionary insights and future directions.

摘要

蚊子已经进化出不同的性别决定染色体，并且它们采用多种主要信号来确定性别。由于只有雌蚊以脊椎动物血液为食，操纵参与性别决定的基因可以促进针对登革热和疟疾等蚊媒传染病的遗传控制措施。我们重点介绍了蚊子性别决定方面的新进展，描述了创新应用，并讨论了相关的进化见解和未来方向。

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