Senba M, Nakamura T, Itakura H
Am J Clin Pathol. 1985 Sep;84(3):340-2. doi: 10.1093/ajcp/84.3.340.
Statistical analysis was carried out to determine the relationships of iron deposition among hepatocytes, Kupffer cells, bile duct epithelial cells, portal tracts, and spleens using 68 autopsy cases obtained from Kenya, which included cases of Bantu siderosis. Of 68 cases, 33 (49%) showed siderosis. Cirrhosis was observed in 19 cases, of which 10 (53%) showed siderosis. However, there was no correlation between iron deposition and cirrhosis (Pearson chi 2 = 0.6734). The finding suggests that iron accumulation does not lead to cellular injury. On the other hand, there was a strong association between iron deposition in the livers and that in the spleens. There was also a strong correlation between the presence of hepatitis B surface antigen and iron deposition in the Kupffer cells and in the spleens. Therefore, it is suggested that the hepatitis B virus infection affects the iron metabolism of the reticuloendothelial system.
利用从肯尼亚获取的68例尸检病例进行统计分析，以确定肝细胞、库普弗细胞、胆管上皮细胞、门静脉区和脾脏中铁沉积之间的关系，其中包括班图铁沉着症病例。68例病例中，33例（49%）出现铁沉着症。19例观察到肝硬化，其中10例（53%）出现铁沉着症。然而，铁沉积与肝硬化之间无相关性（Pearson卡方检验=0.6734）。该发现表明铁蓄积不会导致细胞损伤。另一方面，肝脏中铁沉积与脾脏中铁沉积之间存在强关联。乙型肝炎表面抗原的存在与库普弗细胞和脾脏中铁沉积之间也存在强相关性。因此，提示乙型肝炎病毒感染影响网状内皮系统的铁代谢。
