Lyu Zonghan, Gudino Andres, Dier Carlos, Sagues Elena, Salinas Ivonne, Chiriboga Gustavo, Setia Shubhangi, Shenoy Navami, Samaniego Edgar A, Jiang Jingfeng
Department of Biomedical Engineering, Michigan Technological University, H-STEM 339, 1400 Townsend Drive, Houghton, MI, 49931, USA.
Center for Biocomputing and Digital Health, Institute of Computing and Cybernetics, Health Research Institute, Michigan Technological University, Houghton, MI, 49931, USA.
Neurosurg Rev. 2025 May 14;48(1):417. doi: 10.1007/s10143-025-03566-2.
A small fraction of intracranial aneurysms (IA) contains intrasaccular thrombosis (IST). This study explores the hemodynamic causes of IST formation in IAs. We performed computational hemodynamic analysis in 26 IAs: 13 thrombosed and 13 non-thrombosed. The IAs in the two cohorts were matching in size and anatomical location. The computational hemodynamic analysis used "patient-specific" IA geometries derived from 3D magnetic resonance imaging. A comprehensive hemodynamic analysis was conducted using commonly used hemodynamic metrics (e.g., wall shear stress [WSS] and its derivative), flow vortex analysis, and velocity informatics. We observed that more flow eddies and endothelial cell activation potential (ECAP) are present in thrombosed IAs. The flow eddies in thrombosed IAs change size and location over a cardiac cycle more significantly than those in non-thrombosed IAs. These two factors, coupled with more flow stagnation and positive WSS divergence in the thrombosed IAs, promoted thrombus formation in the thrombosed IA cohort.
一小部分颅内动脉瘤（IA）存在瘤内血栓形成（IST）。本研究探讨了IA中IST形成的血流动力学原因。我们对26个IA进行了计算血流动力学分析：13个有血栓形成的和13个无血栓形成的。两个队列中的IA在大小和解剖位置上相匹配。计算血流动力学分析使用了源自三维磁共振成像的“患者特异性”IA几何形状。使用常用的血流动力学指标（如壁面剪应力[WSS]及其导数）、流涡分析和速度信息学进行了全面的血流动力学分析。我们观察到，有血栓形成的IA中存在更多的流涡和内皮细胞激活潜能（ECAP）。与无血栓形成的IA相比，有血栓形成的IA中的流涡在心动周期内大小和位置的变化更为显著。这两个因素，再加上有血栓形成的IA中更多的血流停滞和正WSS散度，促进了有血栓形成的IA队列中血栓的形成。
