Farag H, Naguib M
Ann R Coll Surg Engl. 1985 Jul;67(4):257-8.
A prospective randomised trial was conducted to evaluate caudal morphine for pain relief following anal surgery. Thirty-three male patients were divided into two groups. Group I (17 patients) were given morphine 10 mg in saline 25 ml injected into the caudal epidural space at the end of surgery. Group II (16 patients) were given intramuscular morphine 10 mg on request in the postoperative period. Pain was assessed at 2, 6, 12 and 24 hours after surgery using the linear analogue of pain score. There was significant pain relief in Group I compared with Group II. There was no instance of respiratory depression in patients of either group. In Group I, five patients suffered urinary retention and three patients transient pruritus.
进行了一项前瞻性随机试验，以评估尾侧注射吗啡在肛门手术后的止痛效果。33名男性患者被分为两组。第一组（17名患者）在手术结束时将10毫克吗啡溶于25毫升生理盐水中注入尾侧硬膜外腔。第二组（16名患者）在术后根据需要肌内注射10毫克吗啡。术后2、6、12和24小时使用疼痛评分线性模拟法评估疼痛。与第二组相比，第一组的疼痛得到了显著缓解。两组患者均未出现呼吸抑制情况。在第一组中，5名患者出现尿潴留，3名患者出现短暂瘙痒。
