Zhou Shijian, Qin Huijie, Shi Qingnan, Li Sihan, Chen Junyuan, Chen Qiulan
National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Chinese Center for Disease Control and Prevention, Beijing, China.
School of Public Health, Guangxi Medical University, Nanning City, Guangxi Zhuang Autonomous Region, China.
China CDC Wkly. 2025 Apr 4;7(14):453-459. doi: 10.46234/ccdcw2025.075.
Human brucellosis persists as a critical public health challenge in China. Understanding disease clusters and trends is essential for implementing effective control strategies. This study evaluates the epidemiological characteristics and spatiotemporal distribution of brucellosis in China from 2011 to 2023.
Data were obtained from the National Notifiable Disease Reporting System (NNDRS). We conducted descriptive epidemiological analyses and employed SaTScan10.1 and ArcGIS10.7 software to identify disease clusters and generate county (district)-level incidence maps.
The incidence of human brucellosis in Chinese mainland increased substantially between 2011 and 2023, rising from 38,151 cases (2.8/100,000) across 834 counties (25.4%) to 70,439 cases (5.2/100,000) across 2,290 counties (76.9%). A significant upward trend in reported incidence emerged during 2018-2023 (average annual percentage change (AAPC)=14.9%, =0.01). Most cases (89.3%) occurred in individuals aged 25-69 years, with an increasing proportion among those aged over 60 years. While 96.1% of cases were reported in northern provincial-level administrative divisions (PLADs), southern regions demonstrated escalating incidence rates and expanding geographical spread. Southern PLADs exhibited a notable annual increase of 31.5% in reported incidence (<0.01). Counties (districts) with incidence rates exceeding 10 per 100,000 expanded geographically from northwestern pastoral regions to southern areas and from rural to urban settings. Primary spatiotemporal clusters were concentrated in Inner Mongolia and adjacent provincial-level administrative divisions (PLADs), with emerging clusters identified in Yunnan, Guangdong, and Xizang.
The human brucellosis epidemic in China continues to intensify, characterized by rebounding incidence rates and broader geographical distribution across counties (districts). While spatiotemporal clusters remain predominantly centered in Inner Mongolia and neighboring regions, targeted interventions and increased resource allocation for high-risk areas and populations are imperative.
人间布鲁氏菌病在中国仍然是一项严峻的公共卫生挑战。了解疾病聚集情况和趋势对于实施有效的控制策略至关重要。本研究评估了2011年至2023年中国布鲁氏菌病的流行病学特征和时空分布。
数据来自国家法定传染病报告系统（NNDRS）。我们进行了描述性流行病学分析，并使用SaTScan10.1和ArcGIS10.7软件识别疾病聚集区并生成县级发病率地图。
2011年至2023年期间，中国大陆人间布鲁氏菌病发病率大幅上升，从834个县（占25.4%）的38151例（2.8/10万）增至2290个县（占76.9%）的70439例（5.2/10万）。2018 - 2023年期间报告发病率出现显著上升趋势（年均变化百分比（AAPC）=14.9%，=0.01）。大多数病例（89.3%）发生在25至69岁的人群中，60岁以上人群的比例不断增加。虽然96.1%的病例报告来自北方省级行政区（PLADs），但南方地区的发病率呈上升趋势且地理分布不断扩大。南方省级行政区报告发病率显著每年增长31.5%（<0.01）。发病率超过每10万10例的县（区）在地理上从西北牧区扩展到南方地区，从农村扩展到城市地区。主要的时空聚集区集中在内蒙古及相邻省级行政区（PLADs），在云南、广东和西藏发现了新出现的聚集区。
中国人间布鲁氏菌病疫情持续加剧，其特征是发病率反弹且各县（区）地理分布范围扩大。虽然时空聚集区仍主要集中在内蒙古及周边地区，但必须针对高风险地区和人群进行有针对性的干预并增加资源分配。
