Chen Juan, Chong Tie, Li Anxia, Yan Yuanyang, Wei Lijun
Department of Pharmacy, Sanya Central Hospital, Hainan Third People's Hospital, Sanya, China.
Department of Urology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xibei Hospital, Xi'an, China.
Transl Androl Urol. 2025 Apr 30;14(4):1049-1065. doi: 10.21037/tau-2024-652. Epub 2025 Apr 27.
There are huge differences in the disease burden of kidney cancer (KC) between countries and regions in Asia. Therefore, we conducted this study to investigate the KC burden and attributable risk factors in Asia.
We obtained data on the incidence, prevalence, mortality, disability adjusted life years, sociodemographic index (SDI), and attributable risk factors of KC in Asian countries and regions from 1990 to 2021 in the Global Burden of Disease database. Joinpoint regression was used to analyze the overall trend of the change in KC burden in Asia. The health inequalities of KC in Asia were evaluated. The correlation between SDI and KC burden was assessed. Autoregressive integrated moving average was used to predict the KC burden in the next 15 years. The age-period-cohort model evaluated the relative risk (RR) of the KC burden in different dimensions. In addition, frontier analyses were performed in this study. Finally, comprehensive analyses of the attributable risk factors of KC were performed.
The KC burden in Asia showed a significant upward trend from 1990 to 2021. The KC burden was mainly concentrated in relatively wealthy countries and regions (high SDI). In the next 15 years, the KC burden would rise further. The RR of KC generally increased with age and period, and decreased with birth cohorts. The most concerning risk factor for KC was high body mass index (HBMI), and the KC burden attributed to HBMI also indicated a significant upward trend and was positively correlated with SDI.
The KC burden in Asian countries and regions is still rising. Therefore, targeted medical interventions are needed to improve early diagnosis and treatment of KC.
亚洲各国和各地区之间肾癌（KC）的疾病负担存在巨大差异。因此，我们开展了本研究，以调查亚洲的肾癌负担及可归因风险因素。
我们从全球疾病负担数据库中获取了1990年至2021年亚洲国家和地区肾癌的发病率、患病率、死亡率、伤残调整生命年、社会人口指数（SDI）及可归因风险因素的数据。采用Joinpoint回归分析亚洲肾癌负担变化的总体趋势。评估了亚洲肾癌的健康不平等情况。评估了SDI与肾癌负担之间的相关性。采用自回归积分滑动平均法预测未来15年的肾癌负担。年龄-时期-队列模型评估了不同维度下肾癌负担的相对风险（RR）。此外，本研究还进行了前沿分析。最后，对肾癌的可归因风险因素进行了综合分析。
1990年至2021年期间，亚洲的肾癌负担呈显著上升趋势。肾癌负担主要集中在相对富裕的国家和地区（高SDI）。在未来15年，肾癌负担将进一步上升。肾癌的RR一般随年龄和时期增加，随出生队列减少。最值得关注的肾癌风险因素是高体重指数（HBMI），归因于HBMI的肾癌负担也呈显著上升趋势，且与SDI呈正相关。
亚洲国家和地区的肾癌负担仍在上升。因此，需要有针对性的医疗干预措施来改善肾癌的早期诊断和治疗。
