Lu Evelyn Ruoyun, Yeung Wai Lan, Yau Jeffrey Ping Wa, Chu King Sun, Kan Elaine Yee Ling, Chiang Alan Kwok Shing
Department of Pediatrics and Adolescent Medicine, Hong Kong Children's Hospital, Hong Kong, Hong Kong SAR, China.
Department of Pediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
Front Oncol. 2025 May 1;15:1477848. doi: 10.3389/fonc.2025.1477848. eCollection 2025.
Neurolymphomatosis (NL) of the peripheral nerve in pediatrics has never been reported, and ultrasonography (USG) as an investigation modality is rarely used. We report a case of an 11-year-old boy with stage 4 mature high-grade B cell lymphoma who presented with a two-week history of right ulnar neuropathy and left sciatic neuropathy one month after the completion of frontline chemotherapy. This case report illustrates the rare presentation of NL in lymphoma relapse and hopes to emphasize how early identification of this diagnosis and timely treatment are essential. Moreover, this case points out how USG, in the context of palpable mass and localized neurological signs, could facilitate a diagnosis of NL.
小儿周围神经的神经淋巴瘤病（NL）此前从未有过报道，超声检查（USG）作为一种检查方式也很少被使用。我们报告一例11岁男孩，患有4期成熟高级别B细胞淋巴瘤，在一线化疗结束后一个月出现右尺神经病变和左坐骨神经病变两周的病史。本病例报告说明了NL在淋巴瘤复发中的罕见表现，并希望强调早期识别该诊断和及时治疗的重要性。此外，该病例指出在可触及肿块和局限性神经体征的情况下，USG如何有助于NL的诊断。
