Yang Liyuan, Chen Xiaojun, Zhong Mengjiao, Pan Zhiyong, Wu Xiaodan
Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, People's Republic of China.
School of Economics and Management, Beijing University of Posts and Telecommunications, Beijing, China.
PLoS One. 2025 May 16;20(5):e0323369. doi: 10.1371/journal.pone.0323369. eCollection 2025.
First-degree relatives (FDRs) of hereditary colorectal cancer are at an increased risk of cancer and receiving early detection and surveillance on malignancies is an efficacious strategy to reduce cancer-related morbidity and mortality. But there is rare information on screening in this cancer high-risk group in China.
The aim of this study was to explore the detection and surveillance on malignancies and its predictors among FDRs of patients with hereditary CRC based on the largest hereditary colorectal cancer cohort from China.
We conducted an exploratory, descriptive, cross-sectional study. 530 FDRs were recruited from December 2021 to December 2022, evaluated using the questionnaire on knowledge, attitudes and behavior of malignancies early detection and the Champion's Health Belief Model Scale. The main outcome were identified using logistic regression analysis.
Among all the FDRs, only 122 (23.0%) underwent malignancies early detection. The predictors of malignancies early detection included knowledge score (OR = 1.117, P < 0.001), sex (OR = 0.244, P < 0.001), age (OR = 4.627, P < 0.001), marital status (OR = 3.815, P < 0.001), chronic disease history (OR = 2.945, P < 0.01), diagnosis of index patient (OR = 2.876, P < 0.001), attitude about "cancer is preventable" (OR = 3.405, P < 0.05) and "one needs malignancies early detection even if feel healthy" (OR = 16.477, P < 0.001), perceived susceptibility (OR = 1.106, P < 0.05) and self-efficacy (OR = 1.244, P < 0.001).
The uptake of malignancy early detection among FDRs should be improved. Some demographic and health-related characteristics, knowledge score, perceived susceptibility and self-efficacy were the most important predictors of malignancies early detection. Enhancing the recognition of clinical features of hereditary CRC and offering personalized genetic counseling, along with tailored cancer risk assessments, could further optimize individual cancer surveillance and prevention strategies, helping to reduce the risk of malignancies in high-risk populations.
遗传性结直肠癌患者的一级亲属患癌风险增加，对恶性肿瘤进行早期检测和监测是降低癌症相关发病率和死亡率的有效策略。但在中国，关于这个癌症高危人群筛查的信息很少。
本研究旨在基于中国最大的遗传性结直肠癌队列，探讨遗传性结直肠癌患者一级亲属中恶性肿瘤的检测和监测情况及其预测因素。
我们进行了一项探索性、描述性横断面研究。2021年12月至2022年12月招募了530名一级亲属，使用恶性肿瘤早期检测知识、态度和行为问卷以及冠军健康信念模型量表进行评估。主要结局通过逻辑回归分析确定。
在所有一级亲属中，只有122人（23.0%）进行了恶性肿瘤早期检测。恶性肿瘤早期检测的预测因素包括知识得分（OR = 1.117，P < 0.001）、性别（OR = 0.244，P < 0.001）、年龄（OR = 4.627，P < 0.001）、婚姻状况（OR = 3.815，P < 0.001）、慢性病病史（OR = 2.945，P < 0.01）、索引患者的诊断（OR = 2.876，P < 0.001）、对“癌症可预防”的态度（OR = 3.405，P < 0.05）和“即使感觉健康也需要进行恶性肿瘤早期检测”的态度（OR = 16.477，P < 0.001）、感知易感性（OR = 1.106，P < 0.05）和自我效能感（OR = 1.244，P < 0.001）。
应提高一级亲属对恶性肿瘤早期检测的接受度。一些人口统计学和健康相关特征、知识得分、感知易感性和自我效能感是恶性肿瘤早期检测的最重要预测因素。加强对遗传性结直肠癌临床特征的认识，提供个性化的遗传咨询以及量身定制的癌症风险评估，可进一步优化个体癌症监测和预防策略，有助于降低高危人群的恶性肿瘤风险。
