Loftus B G, Price J F
Arch Dis Child. 1985 Aug;60(8):770-2. doi: 10.1136/adc.60.8.770.
Fifty two preschool children with asthma were given a recommended regimen of slow release theophylline. There was wide variation in the metabolism of theophylline. The approach adopted gave disappointing results. Nine children did not comply, and 16 stopped treatment because of side effects. Of the remainder, control of asthma was poor in 15 and satisfactory in 12.
52名患有哮喘的学龄前儿童接受了推荐的缓释茶碱治疗方案。茶碱的代谢存在很大差异。所采用的方法产生了令人失望的结果。9名儿童未遵医嘱，16名因副作用停止治疗。在其余儿童中，15名哮喘控制不佳，12名控制良好。
