McKenzie S, Baillie E
Arch Dis Child. 1978 Dec;53(12):943-6. doi: 10.1136/adc.53.12.943.
Serum theophylline levels were measured throughout the day in 65 asthmatic children receiving one of two slow-release theophylline compounds. There was a wide interindividual variation in levels obtained with similar doses of pure theophylline, and also a wide intraindividaual variation in levels throughout the day, suggesting that the rates of release and/or absorption of theophylline from these compounds are not uniform. There were fewer side effects associated with taking these compounds than with choline theophyllinate.
对65名接受两种缓释茶碱化合物之一治疗的哮喘儿童进行了全天血清茶碱水平测定。使用相似剂量的纯茶碱时，个体间水平存在很大差异，而且全天个体内水平也存在很大差异，这表明这些化合物中茶碱的释放和/或吸收速率并不一致。与服用这些化合物相关的副作用比与胆茶碱相关的副作用少。
