Babbage Thalia, Sayegh Ana L C, Fan Jui-Lin, Gant Nicholas, Paton Julian F R, Fisher James P
Department of Physiology, Manaaki Manawa - The Centre for Heart Research, Faculty of Medical & Health Sciences, University of Auckland, New Zealand; Department of Anaesthesiology, Faculty of Medical & Health Sciences, University of Auckland, New Zealand.
Department of Physiology, Manaaki Manawa - The Centre for Heart Research, Faculty of Medical & Health Sciences, University of Auckland, New Zealand.
J Physiol Sci. 2025 May 15;75(2):100027. doi: 10.1016/j.jphyss.2025.100027.
Heightened central and peripheral chemoreflex sensitivity are associated with poor outcomes, but therapeutic approaches to target them are lacking. Endurance and resistance exercise training improve a multitude of physiological outcomes, but their effects on ventilatory chemoreflex sensitivity are unclear. Accordingly, the cardiorespiratory responses to steady-state isocapnic hypoxia (10 % O, 5-minutes) and hyperoxic hypercapnic rebreathing (5 % CO-95 % O) were compared in endurance, resistance, and untrained groups. Central chemoreflex sensitivity was taken as the slope of the relationship between minute ventilation (V̇) and end-tidal partial pressure of CO. Peripheral chemoreflex sensitivity was determined from the absolute increase in V̇ from baseline to peak V̇ expressed relative to the fall in oxygen saturation. Neither central (P = 0.093) nor peripheral (P = 0.847) ventilatory chemoreflex sensitivities were different between groups. Future investigations should seek to understand whether exercise training modality influences central and peripheral chemoreflex sensitivity in older and clinical populations.
中枢和外周化学反射敏感性增强与不良预后相关，但针对它们的治疗方法尚缺乏。耐力和抗阻运动训练可改善多种生理指标，但其对通气化学反射敏感性的影响尚不清楚。因此，对耐力训练组、抗阻训练组和未训练组进行了比较，观察其对稳态等碳酸血症性低氧（10%氧气，持续5分钟）和高氧高碳酸血症性再呼吸（5%二氧化碳-95%氧气）的心肺反应。中枢化学反射敏感性以分钟通气量（V̇）与呼气末二氧化碳分压之间关系的斜率表示。外周化学反射敏感性通过V̇从基线到峰值V̇的绝对增加量相对于氧饱和度下降量来确定。各组之间中枢（P = 0.093）和外周（P = 0.847）通气化学反射敏感性均无差异。未来的研究应致力于了解运动训练方式是否会影响老年人群和临床人群的中枢和外周化学反射敏感性。
