Mo Wenya, Zhou Tao, Dong Qifei, Chen Yuhan, Hu Xuechun, Xiao Jun, Wang Changming, Xiang Ping
Department of Urology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Graduate School, Bengbu Medical University, Bengbu, China.
PeerJ. 2025 May 14;13:e19419. doi: 10.7717/peerj.19419. eCollection 2025.
The presence of kidney stones in individuals with type 2 diabetes mellitus (T2DM) poses a significant challenge and burden, yet the underlying pathogenesis remains elusive. This study aimed to reveal the relationship between the albumin-bilirubin (ALBI) score and kidney stones in adult patients with T2DM. This cross-sectional study was conducted using data from 9,511 eligible patients. The main outcome of interest was the incidence of kidney stones, with the ALBI score serving as the primary exposure factor. Logistic regression analysis was performed to calculate the odds ratios and 95% confidence intervals for the association between ALBI score and kidney stones. Our study found that a higher ALBI score was independently related to the presence of kidney stones in adult patients with T2DM. When the ALBI score was stratified into tertiles, compared to patients with an ALBI score in the T1 category, those with ALBI scores in the T2 and T3 categories exhibited a significantly higher prevalence of kidney stones after adjusting for multiple potential confounding factors. Additionally, our results revealed a non-linear relationship between ALBI score and the presence of kidney stones, which was further supported by subgroup and interaction analyses. These findings offer preliminary insights that could potentially inform future approaches to understanding kidney stone risk in adults with T2DM. Additional studies are needed to validate our conclusions.
2型糖尿病（T2DM）患者中肾结石的存在构成了重大挑战和负担，但其潜在发病机制仍不清楚。本研究旨在揭示成年T2DM患者白蛋白-胆红素（ALBI）评分与肾结石之间的关系。本横断面研究使用了来自9511名符合条件患者的数据。主要关注的结果是肾结石的发病率，ALBI评分作为主要暴露因素。进行逻辑回归分析以计算ALBI评分与肾结石之间关联的优势比和95%置信区间。我们的研究发现，较高的ALBI评分与成年T2DM患者肾结石的存在独立相关。当将ALBI评分分为三分位数时，与ALBI评分为T1类别的患者相比，在调整多个潜在混杂因素后，ALBI评分为T2和T3类别的患者肾结石患病率显著更高。此外，我们的结果揭示了ALBI评分与肾结石存在之间的非线性关系，亚组和交互分析进一步支持了这一点。这些发现提供了初步见解，可能为未来了解成年T2DM患者肾结石风险的方法提供参考。需要进一步研究来验证我们的结论。
