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Immune perturbation by the ileal microbiota in multiple sclerosis.

作者信息

Jensen Lise Torp, Fugger Lars

机构信息

Department of Clinical Medicine, Aarhus University Hospital, Aarhus 8200, Denmark.

Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital University of Oxford, Oxford OX3 9DS, United Kingdom.

出版信息

Proc Natl Acad Sci U S A. 2025 May 27;122(21):e2506777122. doi: 10.1073/pnas.2506777122. Epub 2025 May 19.

DOI:10.1073/pnas.2506777122
PMID:40388629
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12130880/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c366/12130880/9ccd44df3c1d/pnas.2506777122fig01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c366/12130880/9ccd44df3c1d/pnas.2506777122fig01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c366/12130880/9ccd44df3c1d/pnas.2506777122fig01.jpg

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本文引用的文献

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Multiple sclerosis and gut microbiota: Lachnospiraceae from the ileum of MS twins trigger MS-like disease in germfree transgenic mice-An unbiased functional study.多发性硬化症与肠道微生物群：来自多发性硬化症双胞胎回肠的毛螺菌科在无菌转基因小鼠中引发类似多发性硬化症的疾病——一项无偏倚的功能研究。
Proc Natl Acad Sci U S A. 2025 May 6;122(18):e2419689122. doi: 10.1073/pnas.2419689122. Epub 2025 Apr 21.
2
Oral vancomycin treatment alters levels of indole derivatives and secondary bile acids modulating the expression of mTOR pathway genes in astrocytes during EAE.口服万古霉素治疗可改变吲哚衍生物和次级胆汁酸的水平，在实验性自身免疫性脑脊髓炎期间调节星形胶质细胞中mTOR通路基因的表达。
Brain Behav Immun. 2025 Mar;125:355-370. doi: 10.1016/j.bbi.2025.01.006. Epub 2025 Jan 16.
3
Alterations in Gut Microbiome-Host Relationships After Immune Perturbation in Patients With Multiple Sclerosis.多发性硬化症患者免疫扰动后肠道微生物群与宿主关系的改变。
Neurol Neuroimmunol Neuroinflamm. 2025 Mar;12(2):e200355. doi: 10.1212/NXI.0000000000200355. Epub 2025 Jan 16.
4
Design and reporting of prebiotic and probiotic clinical trials in the context of diet and the gut microbiome.在饮食和肠道微生物组背景下的益生元和益生菌临床试验的设计和报告。
Nat Microbiol. 2024 Nov;9(11):2785-2794. doi: 10.1038/s41564-024-01831-6. Epub 2024 Oct 30.
5
Fecal Microbiome Transplants For Parkinson Disease.用于帕金森病的粪便微生物群移植
JAMA Neurol. 2024 Sep 1;81(9):911-913. doi: 10.1001/jamaneurol.2024.2293.
6
Fecal microbiota transplantation as a therapy for treating ulcerative colitis: an overview of systematic reviews.粪便微生物群移植治疗溃疡性结肠炎：系统评价综述
BMC Microbiol. 2023 Nov 29;23(1):371. doi: 10.1186/s12866-023-03107-1.
7
Microbiota from Alzheimer's patients induce deficits in cognition and hippocampal neurogenesis.阿尔茨海默病患者的微生物组会导致认知功能障碍和海马神经发生缺陷。
Brain. 2023 Dec 1;146(12):4916-4934. doi: 10.1093/brain/awad303.
8
The gut microbiota contributes to the pathogenesis of anorexia nervosa in humans and mice.肠道微生物群有助于人类和小鼠神经性厌食症的发病机制。
Nat Microbiol. 2023 May;8(5):787-802. doi: 10.1038/s41564-023-01355-5. Epub 2023 Apr 17.
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Disease-modifying therapy for multiple sclerosis: Implications for gut microbiota.多发性硬化症的疾病修饰治疗：对肠道微生物群的影响。
Mult Scler Relat Disord. 2023 May;73:104671. doi: 10.1016/j.msard.2023.104671. Epub 2023 Mar 26.
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Int J Mol Sci. 2022 Nov 8;23(22):13665. doi: 10.3390/ijms232213665.