Ünlü Begüm, Yıldız Özer Aysel, Özmen İpek, Polat Mine Gülden
Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Marmara University, Istanbul, Türkiye.
Department of Chest Diseases, Hamidiye Faculty of Medicine, University of Health Sciences, Süreyyapaşa Chest Diseases Thoracic Surgery Training and Research Hospital, Istanbul, Türkiye.
Trials. 2025 May 19;26(1):164. doi: 10.1186/s13063-025-08854-2.
Central nervous system dysfunction is an extrapulmonary complication of chronic obstructive pulmonary disease (COPD), and brain function, particularly frontal lobe function, has been shown to deteriorate. It has also been reported that the time taken to complete a functional test involving a cognitive task is prolonged in patients with COPD. The aim of this study is to evaluate the effect of dual-task performance on motor and cognitive function in COPD and to determine the effect of dual-task exercises delivered in a pulmonary rehabilitation program on cardiopulmonary and musculoskeletal parameters.
COPD patients who are admitted to pulmonary rehabilitation, meet the inclusion criteria, and volunteer to participate will be randomly divided into the pulmonary rehabilitation group (control group) and dual-task exercise group. The Dual Task Exercise Group will continue the established rehabilitation programs. During the walking and balance exercises in the program, they will also do cognitive exercises, which are different from those in the pulmonary rehabilitation control group. The COPD Assessment Questionnaire will be applied, and dyspnea assessment will be done with the Modified Medical Research Council Dyspnea Scale. Mini-Mental State Examination and Frontal Assessment Battery will be used to assess cognitive status. Mini-BESTest: Balance Evaluation Systems Test will be used to assess balance. Functional balance and mobility assessment will be performed with the Timed Up and Go Test and the 10-m Walk Test. The tests will be applied twice, as a single task (normal walking) and a dual task (walking and cognitive task). The 6-min walk test will be used to assess functional capacity. Quality of life will be assessed using the St. George Respiratory Questionnaire. Results of pulmonary function tests performed at routine check-ups will be obtained. Assessments will be repeated at the end of the 8-week exercise program.
Extrapulmonary clinical problems may affect the treatment process in COPD. Studies examining the effect of cognitive dysfunction evaluated dual-task performance in COPD and compared it with healthy controls. Despite the differences in the results, it emphasized that the effects of adding dual-task training to pulmonary rehabilitation should be investigated. Our study may contribute to the literature at this point.
ClinicalTrials.gov ID: NCT05930158 (Date: 14.06.2023).
中枢神经系统功能障碍是慢性阻塞性肺疾病（COPD）的一种肺外并发症，且已表明脑功能，尤其是额叶功能会恶化。也有报道称，COPD患者完成涉及认知任务的功能测试所需时间会延长。本研究的目的是评估双重任务执行对COPD患者运动和认知功能的影响，并确定在肺康复计划中进行的双重任务训练对心肺和肌肉骨骼参数的影响。
入住肺康复中心、符合纳入标准并自愿参与的COPD患者将被随机分为肺康复组（对照组）和双重任务训练组。双重任务训练组将继续既定的康复计划。在该计划的步行和平衡训练期间，他们还将进行认知训练，这与肺康复对照组的训练不同。将应用慢性阻塞性肺疾病评估问卷，并使用改良的医学研究委员会呼吸困难量表进行呼吸困难评估。将使用简易精神状态检查表和额叶评估量表来评估认知状态。Mini-BESTest：平衡评估系统测试将用于评估平衡。将使用定时起立行走测试和10米步行测试进行功能平衡和活动能力评估。这些测试将作为单一任务（正常行走）和双重任务（行走和认知任务）进行两次。6分钟步行测试将用于评估功能能力。将使用圣乔治呼吸问卷评估生活质量。将获取在常规检查时进行的肺功能测试结果。在为期8周的运动计划结束时将重复进行评估。
肺外临床问题可能会影响COPD的治疗过程。研究认知功能障碍影响的研究评估了COPD患者的双重任务执行情况，并将其与健康对照组进行了比较。尽管结果存在差异，但强调应研究在肺康复中增加双重任务训练的效果。我们的研究可能在这一点上对文献有所贡献。
ClinicalTrials.gov标识符：NCT05930158（日期：2023年6月14日）。
