Leibenguth F, Steinmetz H
Biochem Genet. 1976 Apr;14(3-4):299-308. doi: 10.1007/BF00484769.
Keeping Drosophila cultures at 28 C results in elimination of all minor multiple ADH bands, thought to be due to conformational change. Thus in diploid and triploid adults heterozygous for the AdhF and AdhS alleles, relative staining intensities are found for the three bands which were in conformity with the assumption that both alleles are equally expressed. Among all polymorphic strains derived from natural Central European and Mediterranean populations, the strain +Tub is unique in that its AdhF allele is closely linked to a new recessive lethal factor, named 1(2)Stm. All AdhF 1/AdhF 1 pupae are unable to emerge, and die. The lethal effect is obvious 50 hr earlier by retarded eye, bristle, and body wall pigmentation. Although all pupae of the phenotype F die, AdhF allele freqnency scarcely seems to be lowered in this natural population.
将果蝇培养物置于28摄氏度会导致所有次要的多个ADH条带消失，据认为这是由于构象变化所致。因此，在AdhF和AdhS等位基因杂合的二倍体和三倍体成虫中，发现三条带的相对染色强度符合两个等位基因均同等表达的假设。在源自中欧和地中海自然种群的所有多态性品系中，+Tub品系独一无二，因为其AdhF等位基因与一个名为1(2)Stm的新隐性致死因子紧密连锁。所有AdhF 1/AdhF 1蛹都无法羽化并死亡。致死效应通过眼睛、刚毛和体壁色素沉着延迟在早50小时时就很明显。尽管表型为F的所有蛹都会死亡，但在这个自然种群中AdhF等位基因频率似乎几乎没有降低。
