Ruiz-Rodríguez Juan Carlos, Chiscano-Camón Luis, Bajaña Ivan, Ruiz-Sanmartin Adolf, Bastidas Juliana, Maldonado Carolina, Nicolás-Morales Pablo, Cantenys-Molina Sergi, González Juan José, Larrosa Nieves, Ferrer Ricard
Intensive Care Department, Vall d'Hebron Hospital Campus, Vall d'Hebron University Hospital, Barcelona, Spain.
Shock, Organ Dysfunction and Resuscitation Research Group. Vall d'Hebron University Hospital, Vall d'Hebron Hospital Campus., Vall d'Hebron Research Institute (VHIR), Barcelona, Spain.
Crit Care. 2025 May 20;29(1):206. doi: 10.1186/s13054-025-05371-1.
Endotoxin septic shock is marked by severe organ failure and mortality rate that exceeds fifty percent, underscoring the critical need to tailor management strategies. Monitoring -endotoxin activity can guide the initiation and direction of adjunctive treatment for refractory septic shock through hemoadsorption. Thus, intervening based on the pathophysiological foundation may potentially improve outcomes. This represents a step towards precision medicine in the management of septic shock adjunctive therapies, addressing a knowledge gap in this pathology that remains insufficiently defined. Despite its potential, in the setting of refractory septic shock and multiorgan dysfunction with extreme endotoxin activity (EAA ≥ 0.9), the data about efficacy of endotoxin hemoadsorption is scarce.
内毒素性脓毒性休克的特征是严重器官功能衰竭，死亡率超过50%，这突出表明迫切需要制定针对性的管理策略。监测内毒素活性可通过血液吸附指导难治性脓毒性休克辅助治疗的启动和方向。因此，基于病理生理基础进行干预可能会改善治疗结果。这代表了在脓毒性休克辅助治疗管理中向精准医学迈出的一步，填补了这一病理领域中仍未充分明确的知识空白。尽管具有潜力，但在难治性脓毒性休克和伴有极高内毒素活性（EAA≥0.9）的多器官功能障碍的情况下，关于内毒素血液吸附疗效的数据却很少。
