Schroth H J, Oberhausen E
Eur J Nucl Med. 1985;10(3-4):152-4. doi: 10.1007/BF00252725.
Labelled macrophages accumulate in Walker carcinosarcoma-256 after 'in vivo' and 'in vitro' stimulation with a lectin and are therefore theoretically suitable for scintigraphic tumour detection. At present, routine application of the technique in man is precluded by: the use of PHA, and a labelling method for macrophages with considerable limitations to its application and which results in significant uptake of activity in liver and spleen. However, the purpose of the study was primarily to demonstrate the principle of a possible alternative to the use of labelled monoclonal antibodies for the scintigraphic detection of tumours.
用凝集素在“体内”和“体外”刺激后，标记的巨噬细胞会在Walker癌肉瘤-256中积聚，因此从理论上讲适合用于肿瘤闪烁显像检测。目前，该技术在人体中的常规应用受到以下因素的限制：使用PHA，以及一种巨噬细胞标记方法，该方法在应用上有很大局限性，并且会导致肝脏和脾脏大量摄取活性物质。然而，本研究的目的主要是证明一种可能替代使用标记单克隆抗体进行肿瘤闪烁显像检测的方法的原理。
