Dahl J E
Acta Odontol Scand. 1985 Jul;43(3):155-62. doi: 10.3109/00016358509064146.
Effects of multiple injections of the cytotoxic drug doxorubicin hydrochloride (Adriamycin) on incisor mesenchymal cells were studied by light microscopy. Rats were killed 1 day after two and three injections, and 1 day and 5 days after four injections. Doses of 5 and 10 mg/kg were used and given on consecutive days. Necrotic alterations expanded in preodontoblast and basal pulp regions when the total dose was increased and finally embraced the entire progenitive part of the incisor. The necrotic area became encapsulated by cellular predentin produced by differentiated pulp cells to prevent further tissue damage, and commencing regeneration was observed after 5 days. When the total dose was split up, the cytotoxicity of doxorubicin increased.
通过光学显微镜研究了多次注射细胞毒性药物盐酸多柔比星（阿霉素）对切牙间充质细胞的影响。在两次和三次注射后1天，以及四次注射后1天和5天处死大鼠。使用5和10mg/kg的剂量并连续给药。当总剂量增加时，坏死性改变在前成牙本质细胞和牙髓基部区域扩大，最终累及切牙的整个增殖部分。坏死区域被分化的牙髓细胞产生的细胞前期牙本质包裹，以防止进一步的组织损伤，并且在5天后观察到开始再生。当总剂量分开时，多柔比星的细胞毒性增加。
