Nogueira T de O, Stene T, Koppang H S
Scand J Dent Res. 1981 Feb;89(1):48-58. doi: 10.1111/j.1600-0722.1981.tb01277.x.
Colchicine (CLC) in doses of 0.5 and 1.5 mg/kg was administered to 40 female Wistar rats in two equal groups. The animals were sacrificed after 5 h, 24 h, 3 d and 7 d, and the effects of CLC on pulp, odontoblasts and dentin in the continuously growing incisors were studied. With the lowest dose a few arrested mitoses were observed in the germinative part of the pulp after 5 and 24 h. With the highest dose an increasing number of mitoses were observed in the germinative part of the pulp after 5 and 24 h. More incisally the odontoblasts were pale, swollen and granulated after 5 h, and necrotic and disintegrated after 24 h. After 3 and 7 d dentinal derangements, consisting of moderately and severely irregular dentin, osteodentin and a niche-like defect in the labial dentin, were seen. Labially one or two incremental lines traversed the dentin from the apical to the incisal part of the incisors.
将秋水仙碱（CLC）以0.5毫克/千克和1.5毫克/千克的剂量给予40只雌性Wistar大鼠，分为两组，每组数量相等。在5小时、24小时、3天和7天后处死动物，研究CLC对持续生长的切牙牙髓、成牙本质细胞和牙本质的影响。使用最低剂量时，在5小时和24小时后，在牙髓生发部位观察到一些有丝分裂停滞。使用最高剂量时，在5小时和24小时后，在牙髓生发部位观察到有丝分裂数量增加。更靠近切端的部位，成牙本质细胞在5小时后变得苍白、肿胀且颗粒化，在24小时后坏死并解体。在3天和7天后，可见牙本质紊乱，包括中度和重度不规则牙本质、骨样牙本质以及唇侧牙本质中的龛样缺损。在唇侧，一两条生长线从切牙的根尖部延伸至切端部穿过牙本质。
