Carswell F, Oliver J
Respiration. 1985;47(2):138-50. doi: 10.1159/000194760.
Inbred PVG/c rats were sensitized to DNP19-ovalbumin by intraperitoneal injection. Sensitized rats when challenged with antigen developed characteristic brief interruptions of expiratory flow ('expiratory notching'). The functional residual capacity fell in rats challenged with antigen or saline but the fall was greater in those sensitized rats challenged with antigen. No greater alterations in respiratory rate, minute volume, airways resistance or dynamic compliance occurred on antigen as compared with saline challenge of sensitized rats, suggesting that the expression of immediate respiratory hypersensitivity in the rat is different from the asthmatic response in humans. The expiratory notching was reduced if an additional airways resistance was added in series to the tracheostomy tube. This may be explained as a result of reduction in the dynamic compression which normally produced the expiratory notching.
近交系PVG/c大鼠通过腹腔注射对二硝基苯基-19-卵清蛋白致敏。致敏大鼠在受到抗原攻击时会出现特征性的呼气气流短暂中断（“呼气切迹”）。功能残气量在受到抗原或生理盐水攻击的大鼠中均下降，但在受到抗原攻击的致敏大鼠中下降幅度更大。与用生理盐水攻击致敏大鼠相比，用抗原攻击时呼吸频率、每分通气量、气道阻力或动态顺应性没有更大变化，这表明大鼠即刻呼吸超敏反应的表现与人类哮喘反应不同。如果在气管造口管上串联增加额外的气道阻力，呼气切迹会减少。这可能是由于通常产生呼气切迹的动态压缩减少所致。
