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Effect of aerosol challenge with sensitising antigen on the permeability of the surface of the rat trachea in life.

作者信息

Mukherjee S, Heap P, Carswell F

机构信息

Department of Child Health, University of Bristol.

出版信息

Thorax. 1988 Dec;43(12):1007-10. doi: 10.1136/thx.43.12.1007.

DOI:10.1136/thx.43.12.1007
PMID:3238630
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC461617/
Abstract

A rat model of immediate pulmonary hypersensitivity was used to investigate the permeability changes in the tracheal epithelium produced by aerosol challenge with antigen. The rats were sensitised by the intraperitoneal injection of antigen (dinitrophenyl (DNP19) ovalbumin). Sensitised and control animals were then challenged for 60 minutes with an aerosol of the same antigen, which also contained the electron dense pore marker lanthanum. Histological examination and x ray probe microanalysis showed a greater intercellular concentration of lanthanum in the tracheal epithelium in sensitised than in control animals. The results show that in sensitised rats increased intercellular penetrance of antigen can occur after antigen challenge.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b956/461617/2ce3ff3d4245/thorax00276-0063-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b956/461617/db5498bfc181/thorax00276-0062-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b956/461617/2ce3ff3d4245/thorax00276-0063-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b956/461617/db5498bfc181/thorax00276-0062-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b956/461617/2ce3ff3d4245/thorax00276-0063-a.jpg

相似文献

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Effect of aerosol challenge with sensitising antigen on the permeability of the surface of the rat trachea in life.
Thorax. 1988 Dec;43(12):1007-10. doi: 10.1136/thx.43.12.1007.
2
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本文引用的文献

1
The effect of cigarette smoke on the permeability of guinea pig airways.香烟烟雾对豚鼠气道通透性的影响。
Lab Invest. 1980 Jul;43(1):94-100.
2
The fate of inhaled antigen within the respiratory tract of sensitized and unsensitized rats.致敏和未致敏大鼠呼吸道内吸入抗原的命运
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Lanthanum as an electron microscopic stain.镧作为一种电子显微镜染色剂。
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Recent developments in analytical electron microscopy.分析电子显微镜的最新进展。
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Thorax. 1968 Mar;23(2):168-72. doi: 10.1136/thx.23.2.168.
7
Respiratory functional changes on intratracheal challenge of sensitized rats.致敏大鼠气管内激发后的呼吸功能变化
Respiration. 1985;47(2):138-50. doi: 10.1159/000194760.
8
The effect of acute airway inflammation on bronchial reactivity in guinea pigs.急性气道炎症对豚鼠支气管反应性的影响。
Am Rev Respir Dis. 1985 Jul;132(1):7-11. doi: 10.1164/arrd.1985.132.1.7.
9
Sequence of pathologic changes in the airway mucosa of guinea pigs during ozone-induced bronchial hyperreactivity.臭氧诱导豚鼠支气管高反应性过程中气道黏膜的病理变化序列
Am Rev Respir Dis. 1985 Mar;131(3):314-20. doi: 10.1164/arrd.1985.131.3.314.
10
Lanthanum penetration of the trachea after the immediate response of sensitized rats to aerosol antigen.致敏大鼠对气溶胶抗原立即反应后镧在气管中的渗透情况。
Clin Exp Immunol. 1986 Sep;65(3):647-53.