Liu Meixuan, Xu Hongmei, Gu Yunxuan, Zhu Jianhong, Zhang Hongai, Lu Hongwei, Sun Jian, Shen Zhenxing, Cao Junji
Department of Environmental Science and Engineering, Xi'an Jiaotong University, Xi'an 710049, China.
SKLLQG, Key Lab of Aerosol Chemistry & Physics, Institute of Earth Environment, Chinese Academy of Sciences, Xi'an 710061, China.
Environ Health (Wash). 2025 Jan 22;3(5):458-468. doi: 10.1021/envhealth.4c00182. eCollection 2025 May 16.
Rural households in northwest China rely on solid fuels as their main heating energy source in winter, leading to negative health outcomes. This study assessed the concentrations of personal exposure to size-resolved particulate matter and gaseous pollutants (NO, CO, and O) and their effects on biomarkers of inflammation and oxidative stress in 129 rural residents who use solid fuels in the Fenwei Plain in winter. The results showed that NO exposure significantly increased IL-6 and TNF-α in urine (u), O exposure significantly increased 8-OHdG and IL-10 in urine (u), and CO exposure caused significantly increased 8-OHdG in blood (b). Four urine biomarkers positively correlated with systolic blood pressure (SBP); 8-OHdG-b was significantly positively correlated with both SBP and diastolic blood pressure (DBP). Mediation analysis showed that O and CO mediated the association between IL-10-u and SBP and 8-OHdG-b with SBP. O and CO exposure caused by domestic solid fuel combustion may lead to an increase in human SBP by mediating systemic inflammation and oxidative stress. The study emphasizes the urgency of improving rural household heating methods and reducing air pollution to alleviate the burden of diseases associated with hypertension and provides a scientific basis for understanding the pathogenesis and early prevention of hypertension among rural residents in northwest China.
中国西北部的农村家庭在冬季依靠固体燃料作为主要取暖能源，这会导致不良的健康后果。本研究评估了汾渭平原129名冬季使用固体燃料的农村居民个人暴露于粒径分辨颗粒物和气态污染物（NO、CO和O）的浓度，以及这些污染物对炎症和氧化应激生物标志物的影响。结果表明，暴露于NO会显著增加尿液中的IL-6和TNF-α，暴露于O会显著增加尿液中的8-OHdG和IL-10，暴露于CO会导致血液中的8-OHdG显著增加。四种尿液生物标志物与收缩压（SBP）呈正相关；8-OHdG-b与SBP和舒张压（DBP）均呈显著正相关。中介分析表明，O和CO介导了IL-10-u与SBP以及8-OHdG-b与SBP之间的关联。家庭固体燃料燃烧引起的O和CO暴露可能通过介导全身炎症和氧化应激导致人体SBP升高。该研究强调了改善农村家庭取暖方式和减少空气污染以减轻与高血压相关疾病负担的紧迫性，并为了解中国西北部农村居民高血压的发病机制和早期预防提供了科学依据。
