Belapurkar Pranoti, Goyal Pragya, Tiwari-Barua Preeti
Department of Biotechnology, IPS Academy, Rajendra Nagar, AB Road, Indore-452 012, India.
Indian J Pharm Sci. 2014 Nov-Dec;76(6):467-75.
The role of plant extracts and Ayurvedic polyherbal preparations in treating various ailments has been acknowledged since time immemorial. Studies based on the effect of these extracts in treatment of different diseases have also been well documented. Indian medicinal literature also emphasizes the synergistic effect of polyherbal drugs in restoring and rejuvenating immune system. This review focuses on the immunomodulatory potential of the polyherbal preparation, Triphala and its three constituents, Terminalia bellerica, Terminalia chebula and Emblica officinalis. The role of Triphala and its extract has been emphasized in stimulating neutrophil function. Under stress condition such as noise, Triphala significantly prevents elevation of IL-4 levels as well as corrects decreased IL-2 and IFN-γ levels. Under the condition of inflammatory stress its immunosuppressive activity is attributed to its inhibitory action on complement system, humoral immunity, cell mediated immunity and mitogen-induced T-lymphocyte proliferation. The aqueous and alcoholic extracts of the individual constituents reportedly enhance especially the macrophage activation due to their free radical scavenging activity and the ability to neutralize reactive oxygen species. This study thus concludes the use of Triphala and its three individual constituents as potential immunostimulants and/or immunosuppressants further suggests them to be a better alternative for allopathic immunomodulators.
自古以来，植物提取物和阿育吠陀多草药制剂在治疗各种疾病方面的作用就已得到认可。基于这些提取物对不同疾病治疗效果的研究也有充分记载。印度医学文献也强调了多草药药物在恢复和振兴免疫系统方面的协同作用。本综述重点关注多草药制剂三果木及其三种成分，即毗黎勒、诃子和余甘子的免疫调节潜力。三果木及其提取物在刺激中性粒细胞功能方面的作用已得到强调。在诸如噪音等应激条件下，三果木能显著防止白细胞介素-4水平升高，并纠正白细胞介素-2和干扰素-γ水平降低。在炎症应激条件下，其免疫抑制活性归因于对补体系统、体液免疫、细胞介导免疫和丝裂原诱导的T淋巴细胞增殖的抑制作用。据报道，各成分的水提取物和醇提取物因其自由基清除活性和中和活性氧的能力，尤其能增强巨噬细胞的激活。因此，本研究得出结论，使用三果木及其三种单一成分作为潜在的免疫刺激剂和/或免疫抑制剂，进一步表明它们是对抗疗法免疫调节剂的更好替代品。
