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计算解剖学:小脑微区计算

Computational anatomy: the cerebellar microzone computation.

作者信息

Gilbert Mike, Rasmussen Anders

机构信息

School of Psychology, College of Life and Environmental Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom.

Department of Experimental Medical Science, Lund University, BMC F10, 22184 Lund, Sweden.

出版信息

Oxf Open Neurosci. 2025 May 16;4:kvaf001. doi: 10.1093/oons/kvaf001. eCollection 2025.

DOI:10.1093/oons/kvaf001
PMID:40401259
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12089033/
Abstract

The cerebellum is a large brain structure. Most of the mass and volume of the cerebellum is made up by the cerebellar cortex. The outer layer of the cerebellar cortex is divided functionally into long, thin strips called microzones. We argue that the cerebellar microzone computation is the aggregate of simple unit computations and a passive effect of anatomy, unaided and unlearned, which we recreate This is likely to polarise opinion. In the traditional view, data processing by the cerebellum (stated very briefly) is the effect of learned synaptic changes. However, this has become difficult to reconcile with evidence that rate information is linearly conserved in cerebellar signalling. We present an alternative interpretation of cell morphologies and network architecture in the light of linear communication. Parallel fibre synaptic memory has a supporting role in the network computation.

摘要

小脑是一个大型脑结构。小脑的大部分质量和体积由小脑皮质构成。小脑皮质的外层在功能上被划分为称为微区的长而细的条带。我们认为,小脑微区计算是简单单元计算的总和,是一种未经辅助和学习的解剖学被动效应,我们对其进行了重现。这可能会使观点两极分化。在传统观点中,(简要地说)小脑的数据处理是学习到的突触变化的结果。然而,这已难以与速率信息在小脑信号传导中线性守恒的证据相协调。我们根据线性通信对细胞形态和网络架构提出了一种替代性解释。平行纤维突触记忆在网络计算中起辅助作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15c5/12089033/bc6796a51219/kvaf001f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15c5/12089033/9948ad085c2f/kvaf001f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15c5/12089033/26d91fc7cd12/kvaf001f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15c5/12089033/6b0ddf03b47b/kvaf001f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15c5/12089033/4d3764156803/kvaf001f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15c5/12089033/8048a8b0931f/kvaf001f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15c5/12089033/bc6796a51219/kvaf001f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15c5/12089033/9948ad085c2f/kvaf001f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15c5/12089033/26d91fc7cd12/kvaf001f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15c5/12089033/6b0ddf03b47b/kvaf001f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15c5/12089033/4d3764156803/kvaf001f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15c5/12089033/8048a8b0931f/kvaf001f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15c5/12089033/bc6796a51219/kvaf001f6.jpg

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本文引用的文献

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The cerebellum converts input data into a hyper low-resolution granule cell code with spatial dimensions: a hypothesis.小脑将输入数据转换为具有空间维度的超低分辨率颗粒细胞编码:一种假说。
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Gap Junctions May Have A Computational Function In The Cerebellum: A Hypothesis.缝隙连接可能在小脑中有计算功能:一个假说。
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The deep cerebellar nuclei to striatum disynaptic connection contributes to skilled forelimb movement.
小脑深部核团至纹状体的双突触连接有助于熟练的前肢运动。
Cell Rep. 2023 Jan 31;42(1):112000. doi: 10.1016/j.celrep.2023.112000. Epub 2023 Jan 18.
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Postsynaptic plasticity of Purkinje cells in mice is determined by molecular identity.小鼠浦肯野细胞的突触后可塑性由分子特征决定。
Commun Biol. 2022 Dec 3;5(1):1328. doi: 10.1038/s42003-022-04283-y.
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Distinct roles for motor cortical and thalamic inputs to striatum during motor skill learning and execution.在运动技能学习与执行过程中,运动皮层和丘脑输入纹状体的不同作用。
Sci Adv. 2022 Feb 25;8(8):eabk0231. doi: 10.1126/sciadv.abk0231.
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Gating by Memory: a Theory of Learning in the Cerebellum.门控记忆:小脑学习理论。
Cerebellum. 2022 Dec;21(6):926-943. doi: 10.1007/s12311-021-01325-9. Epub 2021 Nov 10.
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The basal ganglia control the detailed kinematics of learned motor skills.基底神经节控制着习得运动技能的详细运动学。
Nat Neurosci. 2021 Sep;24(9):1256-1269. doi: 10.1038/s41593-021-00889-3. Epub 2021 Jul 15.
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Bidirectional learning in upbound and downbound microzones of the cerebellum.小脑上行和下行微区的双向学习。
Nat Rev Neurosci. 2021 Feb;22(2):92-110. doi: 10.1038/s41583-020-00392-x. Epub 2020 Nov 17.
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Regulation of striatal cells and goal-directed behavior by cerebellar outputs.小脑输出对纹状体细胞和目标导向行为的调节。
Nat Commun. 2018 Aug 7;9(1):3133. doi: 10.1038/s41467-018-05565-y.
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Depressed by Learning-Heterogeneity of the Plasticity Rules at Parallel Fiber Synapses onto Purkinje Cells.被平行纤维突触到浦肯野细胞的可塑性规则的学习异质性所压抑。
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