蜜环菌中的抗菌倍半萜芳基酯
Antibacterial sesquiterpene aryl esters from Armillaria mellea.
作者信息
Donnelly D M, Abe F, Coveney D, Fukuda N, O'Reilly J, Polonsky J, Prangé T
出版信息
J Nat Prod. 1985 Jan-Feb;48(1):10-6. doi: 10.1021/np50037a002.
PMID:4040154
Abstract
Investigation of the mycelial extract of Armillaria mellea led to the isolation of the known melleolide (2a) and two new sesquiterpene aryl eters, 4-O-methylmelleolide (2b) and judeol (1c). Their structures were deduced from spectral data and that of (2b) confirmed by X-ray analysis. The new esters (1c) and (2b) showed strong antibacterial activity against gram-positive bacteria.
摘要
对蜜环菌菌丝体提取物的研究导致分离出已知的蜜环菌内酯（2a）以及两种新的倍半萜芳基醚，4-O-甲基蜜环菌内酯（2b）和朱迪醇（1c）。它们的结构通过光谱数据推导得出，（2b）的结构经X射线分析得以确证。新的酯类化合物（1c）和（2b）对革兰氏阳性菌显示出强大的抗菌活性。
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