Delatorre Edson, de Mendonça Gabriela Colombo, Gatti Felipe Donateli, Có Anna Clara Gregório, Del Piero Pereira Julia, Tavares Eric Arrivabene, Nodari Joana Zorzal, Rossi Agata, de Azevedo Suwellen Sardinha Dias, Sacchi Cláudio Tavares, Campos Karoline Rodrigues, Bugno Adriana, Rebello Alves Lyvia Neves, Bonela Lucas André Silva, Goulart Jaqueline Pegoretti, de Jesus Sousa Thiago, Naveca Felipe Gomes, Ribeiro-Rodrigues Rodrigo
Emerg Infect Dis. 2025 Jun;31(6):1178-1188. doi: 10.3201/eid3106.241946. Epub 2025 May 22.
Oropouche virus (OROV), historically endemic to the Amazon, had spread to nearly all Brazil states by 2024; Espírito Santo emerged as a transmission hotspot in the Atlantic Forest biome. We characterized the epidemiologic factors driving OROV spread in nonendemic southeast Brazil, analyzing environmental and agricultural conditions contributing to viral transmission. We tested samples from 29,080 suspected arbovirus-infected patients quantitative reverse transcription PCR for OROV and dengue, chikungunya, Zika, and Mayaro viruses. During March‒June 2024, the state had 339 confirmed OROV cases, demonstrating successful local transmission. Spatial analysis revealed that most cases clustered in municipalities with tropical climates and intensive cacao, robusta coffee, coconut, and pepper cultivation. Phylogenetic analysis identified the Espírito Santo OROV strains as part of the 2022-2024 Amazon lineage. The rapid spread of OROV outside the Amazon highlights its adaptive potential and public health threat, emphasizing the need for enhanced surveillance and targeted control measures.
奥罗普切病毒（OROV）历史上在亚马逊地区流行，到2024年已传播至巴西几乎所有州；圣埃斯皮里图州成为大西洋森林生物群落中的一个传播热点。我们对推动OROV在巴西东南部非流行地区传播的流行病学因素进行了特征分析，分析了促成病毒传播的环境和农业条件。我们对29,080名疑似感染虫媒病毒患者的样本进行了OROV以及登革热、基孔肯雅热、寨卡和马亚罗病毒的定量逆转录PCR检测。在2024年3月至6月期间，该州有339例确诊的OROV病例，表明出现了成功的本地传播。空间分析显示，大多数病例集中在热带气候以及可可、罗布斯塔咖啡、椰子和胡椒种植密集的城市。系统发育分析确定圣埃斯皮里图州的OROV毒株是2022 - 2024年亚马逊谱系的一部分。OROV在亚马逊地区以外的快速传播凸显了其适应潜力和公共卫生威胁，强调需要加强监测和采取有针对性的控制措施。
