Kawakami Y, Yamamoto H, Yoshikawa T, Shida A
Am Rev Respir Dis. 1985 Jul;132(1):89-92. doi: 10.1164/arrd.1985.132.1.89.
To examine age-related variations in respiratory chemosensitivity to hypoxia and hypercapnia, the magnitudes of within-pair variances for ventilatory responses to hypoxia and hypercapnia were measured in 38 pairs of male monozygotic twins. Mean values for the slope factor of end-tidal PO2-ventilation hyperbola (A) were larger in Group I (13 pairs with a mean age of 16.3 +/- SD 0.9 yr) than those in Group II (12 pairs with a mean age of 29.8 +/- 6 yr), and Group III (13 pairs with a mean age of 46 +/- 7.2 yr). The slope factors for end-tidal PCO2-ventilation line (S) were similar among the 3 groups. Within-pair variances for A, A/body surface area (BSA), and Vo (asymptote for ventilation when end-tidal PO2 is infinite) were larger in Groups II and III than in Group I. Within-pair variances for S and S/BSA were also larger in Groups II and III than in Group I, whereas within-pair variances for B (intercept with end-tidal PCO2) were similar among the 3 groups. These results indicate that variations for respiratory chemosensitivity to hypoxia increase during the period from adolescence to adulthood and stay at a similar level thereafter. Variations of hypercapnic chemosensitivity also increase during this period, attenuating thereafter; however, the variation is 7 times larger than that of hypoxic chemosensitivity in the third and fourth decades.
为研究呼吸对低氧和高碳酸血症化学敏感性的年龄相关差异，在38对男性同卵双胞胎中测量了对低氧和高碳酸血症通气反应的配对内方差大小。第一组（13对，平均年龄16.3±标准差0.9岁）的潮气末PO₂-通气双曲线斜率因子（A）的平均值大于第二组（12对，平均年龄29.8±6岁）和第三组（13对，平均年龄46±7.2岁）。三组中潮气末PCO₂-通气线斜率因子（S）相似。第二组和第三组中A、A/体表面积（BSA）以及Vo（潮气末PO₂无穷大时的通气渐近线）的配对内方差大于第一组。第二组和第三组中S和S/BSA的配对内方差也大于第一组，而三组中B（与潮气末PCO₂的截距）的配对内方差相似。这些结果表明，从青春期到成年期，呼吸对低氧化学敏感性的变异性增加，此后保持在相似水平。高碳酸血症化学敏感性的变异性在此期间也增加，此后减弱；然而，在第三和第四个十年中，其变异性比低氧化学敏感性大7倍。
