将尿酸提升为抗疟靶点。
Elevating uric acid as an antimalarial target.
作者信息
Drobish Ian, Ackerman Hans
机构信息
Physiology Unit, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA; Critical Care Medicine Department, NIH Clinical Center, Bethesda, MD, USA; Division of Infectious Diseases, Children's National Hospital, Washington, DC, USA.
Physiology Unit, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
出版信息
Trends Parasitol. 2025 Jul;41(7):518-520. doi: 10.1016/j.pt.2025.05.002. Epub 2025 May 21.
Malaria causes hundreds of thousands of deaths each year in children, and many survivors are left with lasting neurological injury. While we have effective parasite-killing drugs, we need treatments that target disease mechanisms to improve outcomes. Bond et al. recently reported uric acid as a potential target for anti-disease therapy.
疟疾每年导致数十万儿童死亡，许多幸存者会留下永久性神经损伤。虽然我们有有效的杀寄生虫药物，但我们需要针对疾病机制的治疗方法来改善治疗效果。邦德等人最近报告称尿酸是抗疾病治疗的一个潜在靶点。
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