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本文引用的文献

1
Elevated uric acid levels, mortality and cognitive impairment in children with severe malaria.严重疟疾患儿的尿酸水平升高、死亡率及认知障碍
Nat Med. 2025 Mar;31(3):777-787. doi: 10.1038/s41591-024-03430-8. Epub 2025 Jan 24.
2
Targeting uric acid: a promising intervention against oxidative stress and neuroinflammation in neurodegenerative diseases.靶向尿酸：一种针对神经退行性疾病中氧化应激和神经炎症的有前景的干预措施。
Cell Commun Signal. 2025 Jan 3;23(1):4. doi: 10.1186/s12964-024-01965-4.
3
Association of uric acid levels with severity of Plasmodium infections: a systematic review and meta-analysis.尿酸水平与疟原虫感染严重程度的关联：系统评价和荟萃分析。
Sci Rep. 2023 Sep 11;13(1):14979. doi: 10.1038/s41598-023-42217-8.
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Xanthine oxidoreductase: One enzyme for multiple physiological tasks.黄嘌呤氧化还原酶：一种酶，多种生理功能。
Redox Biol. 2021 May;41:101882. doi: 10.1016/j.redox.2021.101882. Epub 2021 Jan 27.
5
Refining genome-wide associated loci for serum uric acid in individuals with African ancestry.对非裔人群血清尿酸的全基因组关联位点进行精细化研究。
Hum Mol Genet. 2020 Feb 1;29(3):506-514. doi: 10.1093/hmg/ddz272.
6
Human Mutations in SLC2A9 (Glut9) Affect Transport Capacity for Urate.SLC2A9（Glut9）基因的人类突变影响尿酸转运能力。
Front Physiol. 2018 Jun 18;9:476. doi: 10.3389/fphys.2018.00476. eCollection 2018.
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Recent advances on uric acid transporters.尿酸转运蛋白的最新进展。
Oncotarget. 2017 Aug 10;8(59):100852-100862. doi: 10.18632/oncotarget.20135. eCollection 2017 Nov 21.
8
Plasmodium-induced inflammation by uric acid.疟原虫诱导的尿酸炎症反应。
PLoS Pathog. 2008 Mar 7;4(3):e1000013. doi: 10.1371/journal.ppat.1000013.
9
Molecular identification of a danger signal that alerts the immune system to dying cells.一种向免疫系统警示细胞死亡的危险信号的分子鉴定。
Nature. 2003 Oct 2;425(6957):516-21. doi: 10.1038/nature01991. Epub 2003 Sep 7.

将尿酸提升为抗疟靶点。

Elevating uric acid as an antimalarial target.

作者信息

Drobish Ian, Ackerman Hans

机构信息

Physiology Unit, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA; Critical Care Medicine Department, NIH Clinical Center, Bethesda, MD, USA; Division of Infectious Diseases, Children's National Hospital, Washington, DC, USA.

Physiology Unit, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.

出版信息

Trends Parasitol. 2025 Jul;41(7):518-520. doi: 10.1016/j.pt.2025.05.002. Epub 2025 May 21.

DOI:10.1016/j.pt.2025.05.002
PMID:40404548
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12226212/
Abstract

Malaria causes hundreds of thousands of deaths each year in children, and many survivors are left with lasting neurological injury. While we have effective parasite-killing drugs, we need treatments that target disease mechanisms to improve outcomes. Bond et al. recently reported uric acid as a potential target for anti-disease therapy.

摘要

疟疾每年导致数十万儿童死亡，许多幸存者会留下永久性神经损伤。虽然我们有有效的杀寄生虫药物，但我们需要针对疾病机制的治疗方法来改善治疗效果。邦德等人最近报告称尿酸是抗疾病治疗的一个潜在靶点。