Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts.
Bascom Palmer Eye Institute, Department of Ophthalmology University of Miami, Miami, Florida, USA.
Curr Opin Ophthalmol. 2021 Jul 1;32(4):369-378. doi: 10.1097/ICU.0000000000000771.
This review will discuss the utility of high-resolution anterior segment optical coherence tomography (HR-OCT), in-vivo confocal microscopy (IVCM) and ultrasound biomicroscopy (UBM) in characterizing and diagnosing various ocular surface tumors, namely ocular surface squamous neoplasia (OSSN), conjunctival lymphoma and conjunctival melanoma. The strengths and limitations of each imaging modality will be discussed along with the characteristics findings of each lesion on each imaging platform.
HR-OCT can consistently be utilized in the clinic setting to distinguish between epithelial ocular surface tumors such as OSSN as compared with subepithelial tumors such as conjunctival lymphoma and conjunctival melanoma given their distinctive findings. IVCM can be used as an adjunct to HR-OCT to obtain cellular and surface characteristics, whereas UBM can be used to assess tumor depth and thickness for larger and highly pigmented lesions as well as to detect intraocular invasion.
HR-OCT, IVCM and UBM are all helpful imaging modalities to diagnose and characterize various ocular surface tumors and can serve as valuable adjuncts to monitor treatment response and assess for recurrence ocular surface tumors.
本篇综述将讨论高分辨率眼前节光学相干断层扫描（HR-OCT）、活体共聚焦显微镜（IVCM）和超声生物显微镜（UBM）在各种眼表肿瘤（包括眼表鳞状上皮肿瘤（OSSN）、结膜淋巴瘤和结膜黑色素瘤）的特征和诊断中的应用。将讨论每种成像方式的优缺点，以及每种病变在每种成像平台上的特征性发现。
HR-OCT 可在临床环境中用于区分上皮性眼表肿瘤，如 OSSN，与结膜淋巴瘤和结膜黑色素瘤等上皮下肿瘤，因为它们具有不同的发现。IVCM 可作为 HR-OCT 的辅助手段，用于获取细胞和表面特征，而 UBM 可用于评估较大和高度色素沉着病变的肿瘤深度和厚度，以及检测眼内侵犯。
HR-OCT、IVCM 和 UBM 都是有助于诊断和特征化各种眼表肿瘤的成像方式，可作为监测治疗反应和评估眼表肿瘤复发的有价值的辅助手段。
