Marei Hany E
Department of Cytology and Histology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35116, Egypt.
Stem Cell Res Ther. 2025 May 22;16(1):255. doi: 10.1186/s13287-025-04334-1.
This review article examines how stem cell therapies can cure various diseases and injuries while also discussing the difficulties and moral conundrums that come with their application. The article focuses on the revolutionary developments in stem cell research, especially the introduction of gene editing tools like CRISPR-Cas9, which can potentially improve the safety and effectiveness of stem cell-based treatments. To guarantee the responsible use of stem cells in clinical applications, it is also argued that standardizing clinical procedures and fortifying ethical and regulatory frameworks are essential first steps. The assessment also highlights the substantial obstacles that still need to be addressed, such as the moral dilemmas raised by the use of embryonic stem cells, the dangers of unlicensed stem cell clinics, and the difficulties in obtaining and paying for care for patients. The study emphasizes how critical it is to address these problems to stop exploitation, guarantee patient safety, and increase the accessibility of stem cell therapy. The review also addresses the significance of thorough clinical trials, public education, and policy development to guarantee that stem cell research may fulfill its full potential. The review concludes by describing stem cell research as a promising but complicated topic that necessitates a thorough evaluation of both the hazards and the benefits. To overcome the ethical, legal, and accessibility obstacles and eventually guarantee that stem cell treatments may be safely and fairly included in conventional healthcare, it urges cooperation between the scientific community, legislators, and the general public.
这篇综述文章探讨了干细胞疗法如何治愈各种疾病和损伤，同时也讨论了其应用过程中出现的困难和道德难题。文章重点关注干细胞研究的革命性进展，尤其是像CRISPR-Cas9这样的基因编辑工具的引入，这有可能提高基于干细胞治疗的安全性和有效性。文章还指出，规范临床程序以及加强伦理和监管框架是确保干细胞在临床应用中得到合理使用的关键第一步。评估还强调了仍需解决的重大障碍，比如使用胚胎干细胞引发的道德困境、无证干细胞诊所的风险，以及患者获得治疗和支付治疗费用的困难。该研究强调了解决这些问题对于防止滥用、确保患者安全以及提高干细胞治疗可及性的至关重要性。综述还阐述了全面的临床试验、公众教育和政策制定对于确保干细胞研究充分发挥其潜力的重要意义。综述最后将干细胞研究描述为一个充满希望但又复杂的课题，需要对风险和益处进行全面评估。它敦促科学界、立法者和公众之间开展合作，以克服伦理、法律和可及性障碍，并最终确保干细胞治疗能够安全、公平地纳入传统医疗保健体系。
