从2024年多种麻疹基因型D8的传入，到2025年1月至4月意大利北部米兰及其周边地区B3基因型的持续本地传播。

From multiple measles genotype D8 introductions in 2024 to sustained B3 local transmission in and around Milan, northern Italy, January to April 2025.

作者信息

Fappani Clara, Gori Maria, Bianchi Silvia, Tieghi Lucia, Colzani Daniela, Senatore Sabrina, Faccini Marino, Pasutto Priscilla, Imeri Luca, Vezzosi Luigi, Del Castillo Gabriele, Villa Simone, Cereda Danilo, Gioacchini Silvia, Bucci Paola, Fioravanti Raoul, D'Ugo Emilio, Baggieri Melissa, Magurano Fabio, Amendola Antonella

机构信息

Department of Health Sciences, Università degli Studi di Milano, Milan, Italy.

Coordinated Research Centre "EpiSoMI", Università degli Studi di Milano, Milan, Italy.

出版信息

Euro Surveill. 2025 May;30(20). doi: 10.2807/1560-7917.ES.2025.30.20.2500315.

DOI:10.2807/1560-7917.ES.2025.30.20.2500315

PMID:40406884

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12105090/

Abstract

An outbreak of measles virus genotype B3 is ongoing in Milan and surrounding areas since February 2025, with 27 cases identified in 32 laboratory-confirmed measles cases. Most cases were locally acquired and young adults. Phylogenetic analysis indicated the presence of a unique lineage closely related to strains circulating in Morocco. The lack of epidemiological links between several affected individuals suggests case numbers are being underestimated. The continuous transmission raises concerns about the potential re-establishment of endemic circulation in northern Italy.

摘要

自2025年2月以来，米兰及其周边地区正在爆发B3型麻疹病毒疫情，在32例实验室确诊的麻疹病例中发现了27例。大多数病例是在当地感染的，患者以年轻人为主。系统发育分析表明存在一个与摩洛哥流行毒株密切相关的独特谱系。几名受影响个体之间缺乏流行病学联系，这表明病例数可能被低估了。病毒的持续传播引发了人们对意大利北部可能重新建立地方性传播的担忧。