Tekin Aybüke, Tornacı Selay, Boyacı Defne, Li Suming, Calligaris Sonia, Maalej Hana, Toksoy Öner Ebru
IBSB, Marmara University, Department of Bioengineering, Istanbul, Turkey.
Uskudar American Academy, 34664, Uskudar, Istanbul, Turkey.
Int J Biol Macromol. 2025 Jun;315(Pt 1):144430. doi: 10.1016/j.ijbiomac.2025.144430. Epub 2025 May 21.
Levan is a fructose-based homopolysaccharide renowned for its unique properties, including exceptional adhesive strength, self-assembly capability, low viscosity, and bioactivities such as prebiotic, anti-cancer, anti-inflammatory, and anti-diabetic effects. These characteristics have created increasing interest in levan-based biomaterials over the past decade, positioning levan as a highly under-explored biopolymer for a wide range of applications, from medicine to cosmetics. As a result, levan-based hydrogels have emerged as promising biomaterials in drug delivery, tissue engineering, and cosmetic formulations, owing to their extracellular matrix-mimicking structure, tunable mechanical properties, and controlled cargo release capabilities. This review is the first to comprehensively examine the advancements in levan-based hydrogel research, systematically analyzing their biomedical applications and comparing them with other biopolymer-based hydrogels. Key questions regarding levan's potential as an alternative to established hydrogel systems are explored, highlighting areas requiring further research. By assessing trends and findings in the literature, this review provides an overview of the advantages, limitations, and prospects of levan hydrogels. Our analysis establishes a foundation for the continued development of levan-derived biomaterials, fostering broader adoption in biomedical and industrial applications.
左聚糖是一种基于果糖的同多糖，以其独特的特性而闻名，包括出色的粘附强度、自组装能力、低粘度以及益生元、抗癌、抗炎和抗糖尿病等生物活性。在过去十年中，这些特性使得基于左聚糖的生物材料越来越受到关注，使左聚糖成为一种在从医学到化妆品等广泛应用中未被充分探索的生物聚合物。因此，基于左聚糖的水凝胶因其模仿细胞外基质的结构、可调节的机械性能和可控的药物释放能力，已成为药物递送、组织工程和化妆品配方中很有前景的生物材料。这篇综述首次全面审视了基于左聚糖的水凝胶研究进展，系统分析了它们的生物医学应用，并将其与其他基于生物聚合物的水凝胶进行比较。探讨了有关左聚糖作为现有水凝胶系统替代品潜力的关键问题，突出了需要进一步研究的领域。通过评估文献中的趋势和研究结果，本综述概述了左聚糖水凝胶的优点、局限性和前景。我们的分析为左聚糖衍生生物材料的持续发展奠定了基础，促进其在生物医学和工业应用中的更广泛采用。
