Weiskopf R B, Bogetz M S
Br J Anaesth. 1985 Oct;57(10):1022-5. doi: 10.1093/bja/57.10.1022.
The anaesthetic requirements of ketamine and thiopentone were studied in eight pig littermates during normovolaemia and after haemorrhage (30% blood loss). Four animals received ketamine and four thiopentone, and the minimal anaesthetic doses of both drugs were determined. Moderate hypovolaemia decreased the anaesthetic requirements significantly and similarly: thiopentone 33 +/- 5%; ketamine 40 +/- 5% (mean +/- SEM).
在八对同窝仔猪中，研究了氯胺酮和硫喷妥钠在血容量正常和出血（失血30%）后的麻醉需求。四只动物接受氯胺酮，四只接受硫喷妥钠，并确定了两种药物的最低麻醉剂量。中度血容量不足显著且相似地降低了麻醉需求：硫喷妥钠降低33±5%；氯胺酮降低40±5%（平均值±标准误）。
