Manani G, Valenti S, Vincenti E, Segatto A, Zanette G, Giron G P, Galzigna L
Institute of Anesthesiology and Intensive Care, University of Padua, Italy.
Eur J Anaesthesiol. 1992 Jan;9(1):43-7.
The hypnotic effects of thiopentone and ketamine were studied in ASA Grade I female patients aged 20-30 without premedication. The dose-response curves of ketamine 0.4 mg kg-1 and thiopentone following ketamine 0.4 mg kg-1 were determined by probit analysis. The interaction between ketamine and thiopentone was found to be an antagonistic one. This effect can be interpreted as a consequence of the different neurophysiological spectra of action of the two drugs.
在未进行术前用药的20至30岁ASA I级女性患者中研究了硫喷妥钠和氯胺酮的催眠作用。通过概率分析确定了0.4 mg/kg氯胺酮以及氯胺酮0.4 mg/kg之后硫喷妥钠的剂量-反应曲线。发现氯胺酮和硫喷妥钠之间的相互作用是拮抗作用。这种效应可以解释为两种药物不同神经生理作用谱的结果。
