Meredith P A, Pasanisi F, Elliott H L, Reid J L
Br J Clin Pharmacol. 1985 Sep;20(3):235-7. doi: 10.1111/j.1365-2125.1985.tb05066.x.
The effects of the acute and continued administration of the calcium antagonist nisoldipine on hepatic and renal blood flow and on renal function were studied in nine normotensive volunteers. There were no significant changes in supine blood pressure or heart rate but acute administration significantly increased both apparent liver blood flow and effective renal plasma flow. With continued administration these increases were attenuated and were not significantly different from placebo after 4 days treatment. Acute nisoldipine administration was also associated with significant increases in glomerular filtration rate and urinary sodium excretion.
在9名血压正常的志愿者中研究了钙拮抗剂尼索地平急性和持续给药对肝血流量、肾血流量及肾功能的影响。仰卧位血压或心率无显著变化，但急性给药显著增加了表观肝血流量和有效肾血浆流量。持续给药后，这些增加减弱，治疗4天后与安慰剂相比无显著差异。急性给予尼索地平还与肾小球滤过率和尿钠排泄显著增加有关。
