Gendenshteĭn E I, Oleĭnikova E A, Morozov N T
Biull Eksp Biol Med. 1980 Nov;90(11):594-6.
Chronic experiments with 110 cats have shown that long-term sensitization with homocardiac antigen (HCA) causes biphasic changes in strophanthine tolerance. The increased susceptibility to strophanthine that occurs during 10 days of sensitization with HCA and depends on dissociation of the mechanisms of specific and nonspecific immunity can be prevented by simultaneous administration of diphenhydramine, methyluracil, hydrocortisone and the beta-adrenoblocker, alpheprol. This increase can be also abolished by premedication with alpheprol and trimecain.
对110只猫进行的慢性实验表明，用同种心脏抗原（HCA）进行长期致敏会导致毒毛花苷耐受性出现双相变化。在用HCA致敏10天期间出现的对毒毛花苷敏感性增加，且这种增加取决于特异性和非特异性免疫机制的解离，可通过同时给予苯海拉明、甲基尿嘧啶、氢化可的松和β-肾上腺素能阻滞剂阿普洛尔来预防。这种增加也可通过预先使用阿普洛尔和三甲卡因来消除。
