Melzack R, Rosberger Z, Hollingsworth M L, Thirlwell M
CMAJ. 1985 Oct 15;133(8):755-8, 761.
Valid measures of nausea are needed to evaluate the various treatments used to counter the nausea produced by chemotherapy. The overall nausea intensity (ONI) produced by 17 chemotherapy drugs was estimated by 17 physicians and 8 nurses, and 25 patients undergoing chemotherapy described the subjective qualities and ONI of their nausea on a modified form of the McGill Pain Questionnaire. The scores for the affective and miscellaneous categories of words in the questionnaire were found to correlate significantly with the physicians' and nurses' ONI estimates. The results formed the basis for the Nausea Questionnaire, which provided three indices of nausea: a nausea rating index (NRI), ONI and intensity of nausea according to a visual analogue scale (VAS). All three indices correlated significantly with the physicians' and nurses' ONI estimates and were significantly intercorrelated. All three also provided significant differences when the scores of patients who had received cisplatin or 5-fluorouracil were compared. The results indicate that the Nausea Questionnaire provides three valid indices of the subjective experience of nausea.
需要有效的恶心评估指标来评价用于对抗化疗所致恶心的各种治疗方法。17名医生和8名护士对17种化疗药物产生的总体恶心强度（ONI）进行了评估，25名接受化疗的患者在一份修改版的麦吉尔疼痛问卷上描述了他们恶心的主观感受和ONI。发现问卷中情感类和其他类词汇的得分与医生和护士的ONI评估显著相关。这些结果构成了恶心问卷的基础，该问卷提供了三个恶心指标：恶心评分指数（NRI）、ONI和根据视觉模拟量表（VAS）得出的恶心强度。所有这三个指标与医生和护士的ONI评估均显著相关，且彼此之间显著相关。当比较接受顺铂或5-氟尿嘧啶治疗的患者得分时，所有这三个指标也显示出显著差异。结果表明，恶心问卷提供了三个有效的恶心主观体验指标。
