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物种复合体:梅奇尼科夫酵母科进化枝中新兴的真菌病原体

species complex: emerging fungal pathogens of the Metschnikowiaceae clade.

作者信息

Cao Chengjun, Bing Jian, Liao Guojian, Nobile Clarissa J, Huang Guanghua

机构信息

The Medical Research Institute, College of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, China.

Shanghai Institute of Infectious Disease and Biosecurity, Department of Infectious Diseases, Huashan Hospital and State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, 200438, China.

出版信息

Zoonoses. 2023 Jan 3;3(1). doi: 10.15212/zoonoses-2023-0021. Epub 2023 Oct 31.

Abstract

species represent the most common fungal pathogens of humans, causing not only superficial infections but also life-threatening invasive infections, especially in immunocompromised individuals. While remains the most frequent cause of candidiasis, infections caused by non- species have been increasingly reported in clinical settings over the past two decades. Recently, species of the Metschnikowiaceae clade including the "superbug" and other members of the species complex have attracted significant attention due to their multidrug resistance and high rates of transmission in clinical settings. In this review, we summarize the epidemiology, biology, virulence, and drug resistance of the species complex and discuss potential reasons for the recent increase in prevalence of infections caused by non- species in clinical settings.

摘要

念珠菌属是人类最常见的真菌病原体,不仅会引起浅表感染,还会引发危及生命的侵袭性感染,尤其是在免疫功能低下的个体中。虽然白色念珠菌仍然是念珠菌病最常见的病因,但在过去二十年中,临床环境中由非白色念珠菌引起的感染报告越来越多。最近,包括“超级细菌”光滑念珠菌和光滑念珠菌复合种的其他成员在内的梅奇尼科夫酵母科进化枝的菌种,因其多重耐药性和在临床环境中的高传播率而备受关注。在这篇综述中,我们总结了光滑念珠菌复合种的流行病学、生物学、毒力和耐药性,并讨论了临床环境中非白色念珠菌引起的感染患病率近期上升的潜在原因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d36/11376483/e3b377c16d1b/nihms-1970622-f0002.jpg

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