Liu F, Hu Z-D, Zhao X-M, Zhao W-N, Feng Z-X, Yurkov A, Alwasel S, Boekhout T, Bensch K, Hui F-L, Bai F-Y, Wang Q-M
School of Life Sciences, Institute of Life Sciences and Green Development, Hebei University, Baoding 071002, Hebei, China.
Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany.
Persoonia. 2024 Aug;52:22-43. doi: 10.3767/persoonia.2024.52.02. Epub 2024 Apr 6.
is a polyphyletic genus of asexually reproducing yeasts in the with more than 400 species that occur in almost all families of the subclass and its name is strongly connected with the infectious disease candidiasis. During the last two decades, approximately half of the species have been reassigned into more than 36 already existing genera and 14 newly proposed genera, but the polyphyletic feature of the genus largely remained. is an important, globally emerging opportunistic pathogen that has caused life-threatening outbreaks in healthcare facilities worldwide. This species belongs to the (CAH) clade in the , a clade that contains multidrug-resistant clinically relevant species, but also species isolated from natural environments. The clade is phylogenetically positioned remotely from the type species of the genus that is (currently interpreted as a synonym of ) and belongs to the family . Although previous phylogenetic and phylogenomic studies confirmed the position of in the , these analyses failed to resolve the position of the CAH clade within the family and its delimitation from the genera and . To resolve the position of the CAH clade, phylogenomic and comparative genomics analyses were carried out to address the phylogenetic position of and related species in the using several metrics, such as the average amino acid identity (AAI) values, the percentage of conserved proteins (POCP) and the presence-absence patterns of orthologs (PAPO). Based on those approaches, 13 new genera are proposed for various and species, including members of the CAH clade in the . As a result, and related species are reassigned to the genus . Fifty-five new combinations and nine new species are introduced and this will reduce the polyphyly of the genus . : Liu F, Hu Z-D, Zhao X-M, et al. 2024. Phylogenomic analysis of the Candida auris-Candida haemuli clade and related taxa in the Metschnikowiaceae, and proposal of thirteen new genera, fifty-five new combinations and nine new species. Persoonia 52: 22-43. https://doi.org/10.3767/persoonia.2024.52.02 .
是子囊菌亚纲中一类进行无性繁殖的酵母的多系属，有400多种，几乎出现在该亚纲的所有科中，其名称与传染病念珠菌病密切相关。在过去二十年中，约一半的该属物种已被重新归类到36个以上已有的属和14个新提出的属中，但该属的多系特征在很大程度上仍然存在。是一种重要的、在全球范围内新兴的机会致病菌，已在全球医疗机构中引发危及生命的疫情爆发。该物种属于梅奇尼科夫酵母科中的耳念珠菌-血耳念珠菌（CAH）进化枝，该进化枝包含耐多药的临床相关物种，也包含从自然环境中分离出的物种。该进化枝在系统发育上与该属的模式种即季也蒙毕赤酵母（目前被解释为季也蒙念珠菌的同义词）相距甚远，属于梅奇尼科夫酵母科。尽管先前的系统发育和系统基因组学研究证实了耳念珠菌在该科中的位置，但这些分析未能解决CAH进化枝在该科中的位置及其与毕赤酵母属和德巴利酵母属的界定问题。为了解决CAH进化枝的位置，开展了系统基因组学和比较基因组学分析，以使用多种指标，如平均氨基酸同一性（AAI）值、保守蛋白百分比（POCP）和直系同源物的有无模式（PAPO），来确定耳念珠菌及其相关物种在梅奇尼科夫酵母科中的系统发育位置。基于这些方法，为各种耳念珠菌和血耳念珠菌物种，包括梅奇尼科夫酵母科中CAH进化枝的成员，提出了13个新属。结果，耳念珠菌及其相关物种被重新归类到新属。引入了55个新组合和9个新物种，这将减少该属的多系性。：刘F、胡Z-D、赵X-M等。2024年。梅奇尼科夫酵母科中耳念珠菌-血耳念珠菌进化枝及相关类群的系统基因组学分析，以及13个新属、55个新组合和9个新物种的提议。《真菌学报》52：22 - 43。https://doi.org/10.3767/persoonia.2024.52.02 。
